Product Details
| Product Name:
AR453588 |
CAS No.:
1065609-00-8 |
| Supply Ability:
10g |
Release date:
2025/07/28 |
Product Introduction
Bioactivity
| Name | AR453588 |
| Description | AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
| In vivo | AR453588 (3-30 mg/kg; p.o) reduces post-prandial glucose in normal C57BL/6J mice and exhibits anti-hyperglycemic activity in a dose-ranging 14-day ob/ob mouse study (3-30 mg/kg; p.o.; once-daily for 14 days). Following AR453588 (10 mg/kg; p.o.) administration, Tmax, AUCinf, Vss, Cmax, and F are 1.0 mL/min/kg, 4.65 h μg/mL, 1.67 μg/mL, and 60.3%, respectively. With AR453588 (1 mg/kg; i.v.) administration, the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg/mL, 0.746 L/kg, and 1.28 hours, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | AR 453588 | AR453588 | AR-453588 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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