AR-R 17779 hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: AR-R 17779 hydrochloride | CAS No.: 178419-42-6 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | AR-R 17779 hydrochloride |
| Description | AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memory in rats, suggesting potential therapeutic applications. Additionally, this compound exhibits anxiolytic properties and can mitigate inflammation by activating anti-inflammatory cholinergic (vagal) pathways [1] [2] [4]. |
| In vitro | AR-R17779 demonstrates a fivefold increase in potency and is 35,000 times more selective for the α7 nicotinic receptor than (-)-nicotine [1]. Additionally, when applied at a concentration of 200 nM for 24 hours, AR-R17779 effectively inhibits LPS-induced TNF production in macrophages [4]. |
| In vivo | AR-R17779, administered intraperitoneally (i.p.) at doses of 1-5 mg/kg twice daily for 7 days, has been shown to improve arthritis symptoms, reduce synovial inflammation, delay the onset of the disease, and protect against joint destruction in male DBA/1 mice aged 8-10 weeks. This compound, when given subcutaneously (s.c.) at 1-10 mg/kg for 3 weeks, also enhances learning in two radial-arm maze tasks and reverses working memory impairments in rats with fimbria-fornix sections. Notably, in an animal model where arthritis was induced with type II collagen following unilateral cervical vagotomy or sham surgery, doses of 1, 2.5, and 5 mg/kg administered i.p. twice daily from day 20 to day 26 led to amelioration of arthritis, delayed disease onset, and reductions in erosive disease, cartilage degradation, synovial inflammation, and TNFα levels in both plasma and synovial tissue. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ARR 17779 hydrochloride | AR-R17779 Hydrochloride | AR-R-17779 Hydrochloride | AR-R 17779 Hydrochloride | AR R 17779 hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $64.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-07-10 | |
| $0.00/1kg |
VIP3Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-07-12 | |
| $0.00/25kg |
VIP5Y
|
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)
|
2025-04-30 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY