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Postion:Product Catalog >AQW051
AQW051
  • AQW051

AQW051 NEW

Price $30 $64 $106
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-16

Product Details

Product Name: AQW051 CAS No.: 669770-29-0
Purity: 99.67% Supply Ability: 10g
Release date: 2025/07/16

Product Introduction

Bioactivity

NameAQW051
DescriptionAQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attractive target for the treatment of cognitive impairments associated with neurological disorders, so VQW-051 is often used in studies of anxiety disorders and acute anxiety.
In vitroAQW-051 binds to recombinant human α7-nACh receptor with a pKD value of 7.56. AQW051 effectively activated the calcium transient in GH3-ha7-22 cells stimulated by recombinant expression of α7-nACh receptor, with a pEC50 value of 7.41[1].
In vivoMice administered orally with AQW051 at 0.03 and 0.3 mg/kg enhances cognitive effects and learning/memory performance. Orally AQW051 1mg/kg each time in rats increasing the social exploration time, demonstrating the antianxiety effect of AQW051[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 4.4 mg/mL (14.95 mM), Sonication is recommended.
Keywordsα7 nAChR | VQW765 | VQW 765 | AQW051 | AQW 051 | AQ W-051 | AQ W 051
Inhibitors RelatedAdiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur
Related Compound LibrariesFailed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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