Anticancer agent 81 NEW
| Price | $1870 | $3780 | $5200 |
| Package | 5mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: Anticancer agent 81 | CAS No.: 2820286-56-2 |
| Supply Ability: 10g | Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | Anticancer agent 81 |
| Description | Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis, and serves as a payload for conjugation with Trastuzumab, forming the antibody-drug conjugate (ADC) T-PBA, which retains Trastuzumab's targeting and internalization properties [1]. |
| In vitro | Anticancer agent 81 (Compound 37b3) exhibits cytotoxicity against SKOV3, MDA-MB-231, and NCI-N87 cells after 72 hours of exposure [1]. It induces DNA interstrand cross-linking at 0-5 μM [1], causes S-phase cell cycle arrest in SKOV3 cells at 0-3 nM over 24 hours, leading to apoptosis after 48 hours [1]. At a 25 nM dosage for 12 hours, it penetrates the nuclei of SKOV3 and MDA-MB-231 cells, targeting DNA [1]. Anticancer agent 81 triggers DDR signaling pathways via DNA cross-linking, activates the caspase cascade, and enhances PARP, resulting in cell cycle arrest and apoptosis [1], while predominantly interacting with the major groove of DNA [1]. |
| In vivo | Administered intravenously at doses of 1-10 mg/kg every three days for a total of four doses, T-PBA markedly inhibited tumor progression in two Her2-positive mouse xenograft models, demonstrating superior efficacy to Trastuzumab [1] with no apparent toxicity or adverse effects. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ADCCytotoxin | ADC Cytotoxin |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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