Anticancer agent 164 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-17 |
Product Details
| Product Name: Anticancer agent 164 | CAS No.: 2235393-30-1 |
| Supply Ability: 10g | Release date: 2025/05/17 |
Product Introduction
Bioactivity
| Name | Anticancer agent 164 |
| Description | CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosphorylation within the PI3K/Akt signaling pathway to exert its effects and suppresses cell proliferation through the inhibition of the MEK/ERK signaling pathway in colorectal cancer [1] [2]. |
| In vitro | CML-IN-1 (compound 7) demonstrated minimal cytotoxicity and enhanced bioactivity in cellular assays (K562, IC50: 0.038 μM) [1]. CML-IN-1 (compound 4) significantly inhibited HCT116 cell proliferation with IC50 values of 8.04 ± 0.94 μM at 48 hours and 5.52 ± 0.42 μM at 72 hours, suppressed colony formation, migration, and invasion in a dose-dependent manner, induced apoptosis, caused cell cycle arrest at the G2/M phase, and inhibited MEK/ERK signaling pathway activation [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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