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Postion:Product Catalog >API>Circulatory system drugs>Angina Pectoris Drugs>Amlodipine Besylate
Amlodipine Besylate
  • Amlodipine Besylate

Amlodipine Besylate NEW

Price $33
Package 500mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-01

Product Details

Product Name: Amlodipine Besylate CAS No.: 111470-99-6
Purity: 99.80% Supply Ability: 10g
Release date: 2025/05/01

Product Introduction

Bioactivity

NameAmlodipine Besylate
DescriptionAmlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.
In vitroAmlodipine is a safe and effective oral medication for treating systemic hypertension in cats. In swine coronary arteries with intact endothelium, Amlodipine notably reduces mean indirect systolic pressure, from 198 mmHg to 155 mmHg.
In vivoIn mice infused with angiotensin II, Amlodipine significantly reduced systolic blood pressure, LOX-1 expression, endothelial dysfunction, aortic hypertrophy, and the production of aortic O2(-) and ONOO(-), alongside a decrease in plasma levels of free 8-F(2)α-isoprostanes. In isolated pre-contracted endothelium-intact porcine coronary arteries, Amlodipine induced NO-mediated relaxation, resulting in a leftward shift of the concentration-relaxation curve toward bradykinin. Electron spin resonance spectroscopy in native endothelial cells revealed that Amlodipine increased NO production and stimulated an 8-fold rise in endothelial cyclic GMP levels. Furthermore, Amlodipine induced NO-mediated relaxation in isolated rat aortic rings, leading to downregulation of B2 receptor expression. In endothelial cells, Amlodipine time-dependently attenuated protein kinase C phosphorylation, similar to endothelial nitric oxide synthase phosphorylation, and also prevented phorbol-12-myristate-13-acetate-induced PKC activation. Amlodipine besylate reduced p85αPI3K, phosphorylated GSK-3β, phosphorylated Akt, Bcl-2, and heat shock transcription factor 1 induced H2O2 content, and inhibited Cyclooxygenase-2, cytosolic cytochrome c, cleaved caspase9, and the increase of cleaved caspase3 in neuronal cell apoptosis.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 5.7 mg/mL (10.05 mM), Sonication is recommended.
DMSO : 50 mg/mL (88.18 mM), Sonication is recommended.
Keywordsoral | Inhibitor | inhibit | hypertension | dihydropyridine | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | antianginal | Amlodipine Besylate | Amlodipine
Inhibitors RelatedNisoldipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | L-Phenylalanine | D-Menthol | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Nifedipine | Otilonium bromide
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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