Product Details
| Product Name:
Amivantamab |
CAS No.:
2171511-58-1 |
| Purity:
99.74% |
Supply Ability:
10g |
| Release date:
2025/07/09 |
Product Introduction
Bioactivity
| Name | Amivantamab |
| Description | Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer. |
| In vitro | In Ba/F3 cells treated with Amivantamab ranging from 0.05 to 1 mg/mL, a significant and dose dependent decrease in Ba/F3 cell viability (P < 0.0001) was observed in all five EGFR Exon20ins mutations. [1] |
| In vivo | Mice were treated with amivantamab, IgG1 control, or vehicle at 30 mg/kg twice per week intraperitoneally. Amivantamab-treated mice showed reduced tumor volumes in the Ba/F3 cells bearing NOD. [1] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | MET | HGFR | EGFR | cMet/HGFR | c-Met | cMet |
| Inhibitors Related | (S)-Afatinib | Osimertinib | Lidocaine Hydrochloride hydrate | L-Ascorbic acid 2-phosphate trisodium | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Genistein | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States