Adenosine receptor inhibitor 1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-23 |
Product Details
| Product Name: Adenosine receptor inhibitor 1 | CAS No.: 2550400-52-5 |
| Supply Ability: 10g | Release date: 2025/07/23 |
Product Introduction
Bioactivity
| Name | Adenosine receptor inhibitor 1 |
| Description | Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR), exhibiting exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties, holding great promise for investigating cancer and neurodegenerative diseases [1]. |
| In vitro | Compound 12d, an adenosine receptor inhibitor, demonstrates metabolic stability with 96.56% and 97.97% of the parent compound remaining after a 120-minute incubation with mouse liver microsomes (MLMs) and rat liver microsomes (RLMs), respectively [1]. |
| In vivo | Adenosine receptor inhibitor 1 administered intraperitoneally (i.p.) at doses of 20, 30, 40 mg/kg demonstrated concentration-dependent antinociceptive effects, reducing the pain response in animal models. Specifically, at a 20 mg/kg dose, it exhibited an anti-inflammatory effect, reducing edema in a carrageenan-induced model, and at doses of 5, 10, 20 mg/kg, it showed significant analgesic effects in mice, reducing pain from peripheral sources. In an 18-26 g male albino Swiss mouse model with chronic pain induced by 5% formalin, doses of 20, 30, 40 mg/kg decreased the licking/biting time of the irritated paw. In 150-180 g male Wistar rats experiencing carrageenan-induced edema, a 20 mg/kg dose inhibited edema by 23.3%, 54.2%, and 66.0% over 1, 2, and 3 hours, respectively. Furthermore, in mice injected with irritants such as phenylbenzoquinone or acetic acid to induce pain, doses of 5, 10, 20 mg/kg led to a decrease in pain manifestations by 32.9%, 54.9%, and 82.0%, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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