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Postion:Product Catalog >AC1903
AC1903
  • AC1903

AC1903 NEW

Price $40 $64 $129
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-20

Product Details

Product Name: AC1903 CAS No.: 831234-13-0
Purity: 98.45% Supply Ability: 10g
Release date: 2025/07/20

Product Introduction

Bioactivity

NameAC1903
DescriptionAC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
Animal ResearchTwice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)[1]
In vivoAC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 32.5 mg/mL (107.13 mM), Sonication is recommended.
KeywordsTRPVChannel | TRPV Channel | TRPChannel | TRPC5 | TRP Channel | Transient receptor potential channels | ros | proteinuria | podocyte loss | kidney disease | Inhibitor | inhibit | HEK-293 | glomerulosclerosis | FSGS | focal segmental | AC-1903 | AC1903 | AC 1903
Inhibitors Related(+)-Camphor | Fingolimod hydrochloride | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Capsaicin | trans-Cinnamaldehyde | Methyl salicylate
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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