
Abemaciclib Nitroso Impurity 43 NEW
Price | Get Latest Price | ||
Package | 10mg | 50mg | 100mg |
Min. Order: | 10mg |
Supply Ability: | 1000 |
Update Time: | 2025-07-18 |
Product Details
Product Name: Abemaciclib Nitroso Impurity 43 | CAS No.: 1231930-57-6 |
Min. Order: 10mg | Purity: 99%+ HPLC |
Supply Ability: 1000 | Release date: 2025/07/18 |
Molecular formula: C25H28F2N8 |
Abemaciclib Nitroso Impurity 43
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com.
Product Information
Product Number: A066043
English Name: Abemaciclib Impurity 43
English Alias: 5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine
CAS Number: 1231930-57-6
Molecular Formula: C??H??F?N?
Molecular Weight: 478.54
Advantages
Well-defined and distinct structure: Contains fluorinated benzimidazole, pyrimidine, and piperazinylmethylpyridine moieties, with structural differences from abemaciclib in substituent positions or types. It can be accurately identified by techniques such as HPLC and LC-MS, providing a specific marker for impurity detection;
High stability and traceability: The conjugated system of polycyclic aromatic structures and multiple amino groups is highly stable. As a by-product of incomplete coupling reactions in abemaciclib synthesis, it directly reflects the efficiency of key steps, improving process tracing accuracy;
High detection sensitivity: The electronegativity of fluorine atoms and strong UV absorption (260-280nm) of the polycyclic conjugated system, combined with characteristic mass response (m/z 479 [M+H]?), enable trace analysis via LC-MS, compatible with pyrimidine-based CDK4/6 inhibitor detection systems.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Abemaciclib Impurity 43 in abemaciclib APIs and formulations, ensuring residual impurities meet quality standards;
Synthesis process optimization: Optimizing coupling reaction conditions (e.g., catalyst selection, temperature) by monitoring impurity content to enhance target product selectivity and reduce by-product formation;
Impurity profile enrichment: Contributing to the completeness of abemaciclib’s impurity profile, providing key data for comprehensive purity assessment and supporting drug registration applications.
Background Description
Research Status
Analytical method validation: Developing UPLC-MS/MS assays for simultaneous quantification of abemaciclib and its impurity 43, achieving detection limits as low as 0.1 ppb for pharmaceutical analysis;
Synthetic efficiency enhancement: Designing novel coupling strategies to minimize impurity formation by improving regioselectivity in benzimidazole-pyrimidine conjugation;
Toxicological screening: Evaluating potential cytotoxicity of the impurity via in vitro cell assays to establish scientifically based impurity limits;
Formulation compatibility studies: Assessing interactions between the impurity and excipients to ensure stability of abemaciclib formulations during shelf life.
Product Information
Product Number: A066043
English Name: Abemaciclib Impurity 43
English Alias: 5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine
CAS Number: 1231930-57-6
Molecular Formula: C??H??F?N?
Molecular Weight: 478.54
Advantages
Well-defined and distinct structure: Contains fluorinated benzimidazole, pyrimidine, and piperazinylmethylpyridine moieties, with structural differences from abemaciclib in substituent positions or types. It can be accurately identified by techniques such as HPLC and LC-MS, providing a specific marker for impurity detection;
High stability and traceability: The conjugated system of polycyclic aromatic structures and multiple amino groups is highly stable. As a by-product of incomplete coupling reactions in abemaciclib synthesis, it directly reflects the efficiency of key steps, improving process tracing accuracy;
High detection sensitivity: The electronegativity of fluorine atoms and strong UV absorption (260-280nm) of the polycyclic conjugated system, combined with characteristic mass response (m/z 479 [M+H]?), enable trace analysis via LC-MS, compatible with pyrimidine-based CDK4/6 inhibitor detection systems.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Abemaciclib Impurity 43 in abemaciclib APIs and formulations, ensuring residual impurities meet quality standards;
Synthesis process optimization: Optimizing coupling reaction conditions (e.g., catalyst selection, temperature) by monitoring impurity content to enhance target product selectivity and reduce by-product formation;
Impurity profile enrichment: Contributing to the completeness of abemaciclib’s impurity profile, providing key data for comprehensive purity assessment and supporting drug registration applications.
Background Description
Research Status
Analytical method validation: Developing UPLC-MS/MS assays for simultaneous quantification of abemaciclib and its impurity 43, achieving detection limits as low as 0.1 ppb for pharmaceutical analysis;
Synthetic efficiency enhancement: Designing novel coupling strategies to minimize impurity formation by improving regioselectivity in benzimidazole-pyrimidine conjugation;
Toxicological screening: Evaluating potential cytotoxicity of the impurity via in vitro cell assays to establish scientifically based impurity limits;
Formulation compatibility studies: Assessing interactions between the impurity and excipients to ensure stability of abemaciclib formulations during shelf life.
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
Company Profile Introduction
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