7,3',4'-Tri-O-methylluteolin NEW
| Price | $89 | $178 | $278 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-16 |
Product Details
| Product Name: 7,3',4'-Tri-O-methylluteolin | CAS No.: 29080-58-8 |
| Purity: 98.99% | Supply Ability: 10g |
| Release date: 2025/05/16 |
Product Introduction
Bioactivity
| Name | 7,3',4'-Tri-O-methylluteolin |
| Description | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) exhibits anti-inflammatory, antibacterial, and antifungal activities, along with moderate antitrypanosomal activity, having an MIC value of 19.0 μg/mL. |
| In vitro | 7,3',4'-Tri-O-methylluteolin significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α±, IL-6, and IL-1β, were obviously reduced by 7,3',4'-Tri-O-methylluteolinin a concentration-dependent manner. Moreover, 7,3',4'-Tri-O-methylluteolinsignificantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 7,3',4'-Tri-O-methylluteolinwith inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions[1] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 9 mg/mL (27.41 mM), Sonication is recommended. |
| Keywords | Tumor Necrosis Factor Receptor | TNF-α | TNFR | TNF Receptor | TNF | RAW 264.7 macrophage | pro-inflammatory cytokines | LOX | lipopolysaccharide | Interleukin Related | Interleukin | Inhibitor | inhibit | Inflammation-related diseases | IL Receptor | Cyclooxygenase | COX | 7,3',4'-Tri-O-methylluteolin | 7,3',4'TriOmethylluteolin | 7,3',4' Tri O methylluteolin |
| Inhibitors Related | Acetaminophen | Aspirin | Salicylamide | Glucosamine | Gallic Acid Monohydrate | Diclofenac Potassium | Apremilast | Meloxicam | Paradol | Salicylic acid | Phenylbutazone | Revaprazan hydrochloride |
| Related Compound Libraries | Flavonoid Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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