Product Details
| Product Name:
5A2-SC8 |
CAS No.:
1857341-90-2 |
| Purity:
≥98% |
Supply Ability:
10g |
| Release date:
2025/07/09 |
Product Introduction
Bioactivity
| Name | 5A2-SC8 |
| Description | 5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery. |
| In vitro | 5A2-SC8 is taken up by hepatocytes by binding to the LDL receptor (LDL-R) on the surface of hepatocytes and undergoing receptor-mediated endocytosis with the aid of a crown of surface-adsorbed ApoE protein. [2] |
| In vivo | A single dose of 75 mg/kg 5A2-SC8 administered intravenously was well tolerated in chronically ill mice with invasive hepatocellular carcinoma and did not adversely affect survival. [1]
Intravenous injection of 0.5 mg/kg 5A2-SC8 was effective in crossing the first barrier of hepatic Kupffer cells and was internalized by hepatocytes after 6 hours in the presence of siFVII labeled with Cy5.5 dye. [2] |
| Storage | keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO : 80 mg/mL (43.44 mM), Sonication is recommended.
|
| Keywords | Liposome |
| Inhibitors Related | G0-C14 HCl | (Rac)-DSPG sodium | NT1-O14B | DSPE-PEG 2000 | DSPE-PEG(2000)-COOH | DSPE-PEG-Azide (MW 2000) | POPG sodium salt | DODAP | DHAPC | C14-4 | DSPG sodium | 4A3-SC8 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1g |
VIP5Y
|
XIAMEN SINOPEG BIOTECH CO., LTD.
|
2024-07-30 |
United States