4-hydroperoxy cyclophosphamide NEW
| Price | $333 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-09 |
Product Details
| Product Name: 4-hydroperoxy cyclophosphamide | CAS No.: 39800-16-3 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2025/07/09 |
Product Introduction
Bioactivity
| Name | 4-hydroperoxy cyclophosphamide |
| Description | 4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases. |
| In vitro | 4-hydroperoxy cyclophosphamide mediates caspase-independent T cell apoptosis through oxidative stress-induced nuclear relocalization of mitochondrial apoptotic factors AIF and EndoG. [1] The combination of 1 μg/mL 4-hydroperoxy cyclophosphamide and methotrexate inhibited IL-6/sil-6r-induced RANKL expression in fibroblast-like synoviocytes through inhibition of JAK2/STAT3 and p38MAPK signaling pathways. [2] |
| In vivo | Intraperitoneal injection of 200 mg/kg 4-hydroperoxy cyclophosphamide resulted in caspase-independent T and B cell death in mice. [1] |
| Storage | store at low temperature,store under nitrogen,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Dichloromethane : <1 mg/mL(insoluble or slightly soluble) DMSO : 30 mg/mL (102.36 mM), Sonication is recommended. Chloroform : <1 mg/mL(insoluble or slightly soluble) |
| Keywords | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | DrugMetabolite | Drug Metabolite | DNAAlkylator | DNA Alkylator/Crosslinker | DNA Alkylator | Crosslinker | Apoptosis | 4-hydroperoxy Cyclophosphamide | 4hydroperoxy Cyclophosphamide | 4 hydroperoxy Cyclophosphamide |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Cysteamine hydrochloride | Acetylcysteine | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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