
(4-Carboxybutyl)triphenylphosphonium bromide NEW
Price | Get Latest Price | |
Package | 1kg | 25kg |
Min. Order: | 1kg |
Supply Ability: | 20MT |
Update Time: | 2025-07-17 |
Product Details
Product Name: (4-Carboxybutyl)triphenylphosphonium bromide | CAS No.: 17814-85-6 |
Min. Order: 1kg | Purity: 98% |
Supply Ability: 20MT | Release date: 2025/07/17 |
1. Organic Synthesis – Wittig Reaction
Water-Soluble Wittig Reagent: The carboxylate group enhances solubility in polar solvents (e.g., water or alcohols), enabling olefination reactions in aqueous or mixed-phase systems.
Functionalized Alkene Synthesis: Used to prepare α,β-unsaturated carboxylic acids or esters after deprotonation (with base) to form the ylide.
Selective Olefination: Useful in pharmaceutical or fine chemical synthesis where carboxylate-tagged alkenes are needed for further derivatization.
2. Bioconjugation & Drug Delivery
Peptide/Protein Modification: The carboxylic acid (–COOH) can be activated (e.g., via EDC/NHS) to conjugate with amines (–NH?) in biomolecules (e.g., antibodies, drugs).
Cationic Carrier: The positively charged phosphonium group may interact with cell membranes or nucleic acids (e.g., DNA/RNA), potentially aiding in gene delivery.
3. Materials Chemistry
Ionic Liquids & Catalysts: Acts as a phase-transfer catalyst (PTC) for reactions in biphasic systems (e.g., nucleophilic substitutions).
Polymer Modification: Incorporated into polymers to introduce cationic charges or carboxyl groups for stimuli-responsive materials.
4. Electrochemistry & Energy Storage
Electrolyte Additive: Phosphonium-based ionic liquids are explored for batteries or supercapacitors due to their thermal stability and ionic conductivity.
5. Analytical & Sensor Applications
Fluorescent Probes: The phosphonium moiety can quench or enhance fluorescence, useful in designing anion or metal-ion sensors.
Key Advantages
Dual Reactivity: Combines phosphonium ylide chemistry (Wittig) and carboxylate coupling (e.g., amide/ester formation).
Water Compatibility: Unlike traditional hydrophobic Wittig reagents, this derivative enables greener chemistry in aqueous media.
Limitations
Steric Hindrance: The triphenylphosphine group may limit reactivity with sterically hindered carbonyl compounds.
Stability: Phosphonium ylides require anhydrous conditions for some reactions.
For specific applications (e.g., drug delivery), further derivatization (e.g., esterification of –COOH) is often needed. Literature examples include its use in synthesizing vitamin D analogs or functionalized polymers.
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- Since: 2018-09-28
- Address: No. 16, 20th Floor, Unit 2, Kaixin Houhu Life Plaza, Tazi Lake, Jiang'an District, Wuhan City, Hubei