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Postion:Product Catalog >Organic Chemistry>Phosphines>(4-Carboxybutyl)triphenylphosphonium bromide
(4-Carboxybutyl)triphenylphosphonium bromide
  • (4-Carboxybutyl)triphenylphosphonium bromide
  • (4-Carboxybutyl)triphenylphosphonium bromide

(4-Carboxybutyl)triphenylphosphonium bromide NEW

Price Get Latest Price
Package 1kg 25kg
Min. Order: 1kg
Supply Ability: 20MT
Update Time: 2025-07-17

Product Details

Product Name: (4-Carboxybutyl)triphenylphosphonium bromide CAS No.: 17814-85-6
Min. Order: 1kg Purity: 98%
Supply Ability: 20MT Release date: 2025/07/17

1. Organic Synthesis – Wittig Reaction 

Water-Soluble Wittig Reagent: The carboxylate group enhances solubility in polar solvents (e.g., water or alcohols), enabling olefination reactions in aqueous or mixed-phase systems.  

Functionalized Alkene Synthesis: Used to prepare α,β-unsaturated carboxylic acids or esters after deprotonation (with base) to form the ylide.  

Selective Olefination: Useful in pharmaceutical or fine chemical synthesis where carboxylate-tagged alkenes are needed for further derivatization.


2. Bioconjugation & Drug Delivery  

Peptide/Protein Modification: The carboxylic acid (–COOH) can be activated (e.g., via EDC/NHS) to conjugate with amines (–NH?) in biomolecules (e.g., antibodies, drugs).  

Cationic Carrier: The positively charged phosphonium group may interact with cell membranes or nucleic acids (e.g., DNA/RNA), potentially aiding in gene delivery.  


3. Materials Chemistry 

Ionic Liquids & Catalysts: Acts as a phase-transfer catalyst (PTC) for reactions in biphasic systems (e.g., nucleophilic substitutions).  

Polymer Modification: Incorporated into polymers to introduce cationic charges or carboxyl groups for stimuli-responsive materials.  


4. Electrochemistry & Energy Storage  

Electrolyte Additive: Phosphonium-based ionic liquids are explored for batteries or supercapacitors due to their thermal stability and ionic conductivity.  


5. Analytical & Sensor Applications  

Fluorescent Probes: The phosphonium moiety can quench or enhance fluorescence, useful in designing anion or metal-ion sensors.  


Key Advantages 

Dual Reactivity: Combines phosphonium ylide chemistry (Wittig) and carboxylate coupling (e.g., amide/ester formation).  

Water Compatibility: Unlike traditional hydrophobic Wittig reagents, this derivative enables greener chemistry in aqueous media.  


Limitations  

Steric Hindrance: The triphenylphosphine group may limit reactivity with sterically hindered carbonyl compounds.  

Stability: Phosphonium ylides require anhydrous conditions for some reactions.  


For specific applications (e.g., drug delivery), further derivatization (e.g., esterification of –COOH) is often needed. Literature examples include its use in synthesizing vitamin D analogs or functionalized polymers.  

Company Profile Introduction

Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance. With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy. At Watson Biotechnology, we pride ourselves on our cutting-edge facilities and state-of-the-art technology, which enable us to deliver superior products that cater to a diverse range of needs across various sectors. Our dedication to continuous improvement and customer satisfaction drives us to maintain stringent quality control processes and foster an environment of innovation and growth. Join us at Watson Biotechnology Co., Ltd as we continue to pioneer advancements in biotechnology and contribute to a healthier, more sustainable future.

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  • Address: No. 16, 20th Floor, Unit 2, Kaixin Houhu Life Plaza, Tazi Lake, Jiang'an District, Wuhan City, Hubei
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