4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE NEW
| Price | Get Latest Price |
| Package | 200kg |
| Min. Order: | 1000kg |
| Supply Ability: | 20 tons |
| Update Time: | 2025-04-02 |
Product Details
| Product Name: 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE | CAS No.: 4316-98-7 |
| Min. Order: 1000kg | Purity: 0.99 |
| Supply Ability: 20 tons | Release date: 2025/04/02 |
4,5-Diamino-6-chloropyrimidine CAS 4316-98-7 | Leading Supplier of High-Activity Aminochloropyrimidine Intermediates
[Core Keywords]: 4,5-Diamino-6-chloropyrimidine supplier, CAS 4316-98-7, aminopyrimidine pharmaceutical intermediates, agrochemical fungicide building blocks, functional material precursors
Product Basics
Chemical Name: 4,5-Diamino-6-chloropyrimidine
CAS No.: 4316-98-7 (Title-level keyword emphasis)
Molecular Formula: C?H?ClN?
Molecular Weight: 144.56 g/mol
Appearance: White to light-yellow crystalline powder
Purity: ≥98.0% (HPLC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|---|
| Melting Point | 285-288℃ (decomposes, DSC-determined) |
| Solubility | Freely soluble in DMSO, dilute HCl; slightly soluble in water; insoluble in ethanol/acetone |
| Stability | Light-sensitive (store in dark), stable at pH 4-8 |
| pKa (25℃) | Amino group: 3.8±0.3, Chlorine substituent: 6.2±0.2 |
| Storage Conditions | Airtight, light-protected, and stored at -20℃ in a dry environment |
Integrated Industry Chain
? Upstream Material Assurance
Core Intermediates: 4,5-Diaminopyrimidine, chlorinating agents (e.g., SOCl?)
Process Optimization: Selective chlorination technology (yield >88%, byproducts <0.5%)
? Downstream Application Expansion
Anticancer Drugs: Key precursor for thymidylate synthase inhibitors
Agrochemical Fungicides: Structural optimization of pyrimidine amine compounds (e.g., mepanipyrim)
Coordination Chemistry: Transition metal complex ligand design (e.g., platinum-based drugs)
Molecular Probes: Development of DNA base analogs
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|---|---|
| Anticancer Drugs | Overcoming 5-fluorouracil resistance | Amino-directed acylation yield >95% (LC-MS verified) |
| Agrochemicals | Resistance-management fungicide R&D | Photostability >90% under UV 254nm |
| Targeted Therapy | Platinum chemotherapeutic enhancers (e.g., oxaliplatin) | Coordination selectivity >98% |
| Diagnostic Reagents | Fluorophore-labeled nucleic acid probe synthesis | Click chemistry efficiency >93% via chlorine substitution |
SEO Keyword Matrix
Core Keywords:
"4,5-Diamino-6-chloropyrimidine price"
"CAS 4316-98-7 technical data"
"High-activity aminochloropyrimidine supplier"
Long-Tail Keywords:
"Thymidylate synthase inhibitor intermediate manufacturer"
"Mepanipyrim API synthesis supplier"
"Pharmaceutical-grade CAS 4316-98-7 producer"
Compliance Statements
? EINECS Status: Not listed (verified via ECHA database)
? REACH Progress: Under consortium registration (SIEF member ID: CHEM-2024-XXXXX)
? EU Export: Supports PPORD exemption (R&D use, annual export <1 ton)
? Analysis Reports: Full documentation provided (HPLC, 1H NMR, elemental analysis)
Company Profile Introduction
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China- Since: 2004-04-13
- Address: No. 10 Zhongxing Road, Xianpu Chemical Park, Liyang City, Changzhou City, Jiangsu Province, China