3,3'-Disulfanediyldipropanoic acid

Modify Date: 2024-01-02 12:41:20

3,3'-Disulfanediyldipropanoic acid structure	Common Name	3,3'-Disulfanediyldipropanoic acid
	CAS Number	1119-62-6	Molecular Weight	210.271
	Density	1.5±0.1 g/cm3	Boiling Point	431.1±30.0 °C at 760 mmHg
	Molecular Formula	C6H10O4S2	Melting Point	155-158 °C(lit.)
	MSDS	ChineseUSA	Flash Point	214.5±24.6 °C
	Symbol	GHS07	Signal Word	Warning

Purity		Quantity		Budget		Inquiry

Use of 3,3'-Disulfanediyldipropanoic acid Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].

• Properties

• Articles7

• Spectrum

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 Names

Name	3,3′-Dithiodipropionic acid
Synonym	More Synonyms

 3,3'-Disulfanediyldipropanoic acid Biological Activity

Description	Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1]. CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1]. CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1].
References	[1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

 Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	431.1±30.0 °C at 760 mmHg
Melting Point	155-158 °C(lit.)
Molecular Formula	C6H10O4S2
Molecular Weight	210.271
Flash Point	214.5±24.6 °C
Exact Mass	210.002045
PSA	125.20000
LogP	1.38
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.592

 MSDS

3,3'-Disulfanediyldipropanoic acid MSDS(Chinese)

 Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C:Corrosive;
Risk Phrases	R34
Safety Phrases	S26-S36
RIDADR	1759
WGK Germany	3
Packaging Group	III
Hazard Class	8
HS Code	2930909090

 Synthetic Route

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3-Mercaptopropi... 107-96-0 ~96% 3,3'-Disulf... 1119-62-6

Literature: Li, Xu-Bing; Li, Zhi-Jun; Gao, Yu-Ji; Meng, Qing-Yuan; Yu, Shan; Weiss, Richard G.; Tung, Chen-Ho; Wu, Li-Zhu Angewandte Chemie - International Edition, 2014 , vol. 53, # 8 p. 2085 - 2089 Angew. Chem., 2014 , vol. 126, # 8 p. 2117 - 2121,5

Iodotrifluorome... 2314-97-8 3-Mercaptopropi... 107-96-0 ~% 3,3'-Disulf... 1119-62-6

Literature: Journal of Fluorine Chemistry, , vol. 132, # 12 p. 1241 - 1246

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 Precursor & DownStream

Precursor  10	Previous 1/3 Next
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DownStream  10	Previous 1/3 Next
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 Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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