2,4-Diamino-6-piperidinopyrimidine NEW
| Price | Get Latest Price |
| Package | 200kg |
| Min. Order: | 1000kg |
| Supply Ability: | 20 tons |
| Update Time: | 2025-04-02 |
Product Details
| Product Name: 2,4-Diamino-6-piperidinopyrimidine | CAS No.: 24867-26-3 |
| Min. Order: 1000kg | Purity: 0.99 |
| Supply Ability: 20 tons | Release date: 2025/04/02 |
2,4-Diamino-5-Piperidinylpyrimidine CAS 24867-26-3 | Leading Supplier of High-Value Heterocyclic Amine Intermediates
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Product Basics
Chemical Name: 2,4-Diamino-5-(piperidin-1-yl)pyrimidine
CAS No.: 24867-26-3 (Title-level keyword emphasis)
Molecular Formula: C?H??N?
Molecular Weight: 193.25 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥99.0% (HPLC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|---|
| Melting Point | 215-218℃ (decomposition, DSC) |
| Solubility | Freely soluble in DMSO, dilute HCl; slightly soluble in MeOH/EtOH; insoluble in acetone |
| pKa (25℃) | Amines: 4.2±0.3, Piperidine N: 8.5±0.5 |
| Stability | Light-protected storage, stable at pH 5-9 (40℃/75% RH accelerated test, 14-day degradation <1%) |
| Storage Conditions | Airtight, light-protected, stored at -20℃ in a dry place |
Integrated Industry Chain
? Upstream Material Assurance
Core Intermediates: 2,4-Diaminopyrimidine, ethyl piperidine-1-carboxylate
Process Optimization: Buchwald-Hartwig coupling technology (conversion >92%, Pd catalyst residue <5 ppm)
? Downstream Application Expansion
Anticancer Drugs: CDK4/6 inhibitor (e.g., palbociclib) scaffold optimization
Agrochemical Insecticides: Neonicotinoid derivative structural modification
Coordination Chemistry: Platinum-based chemotherapeutic (e.g., cisplatin) potentiation ligand design
Molecular Probes: Kinase active site covalent labeling reagents
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|---|---|
| Targeted Therapy | ER+ breast cancer CDK inhibitor resistance breakthrough | Piperidine ring conformational control selectivity >98% (Chiral HPLC verified) |
| Agrochemicals | Imidacloprid derivative resistance management | Lipophilicity (LogP=1.8) precise tuning |
| Metallodrugs | Platinum complex tumor-targeted delivery system | Coordination constant (log K) >5.2 (Pt2?) |
| Chemical Biology | Kinase ATP-binding pocket covalent probe | Amino-directed acylation yield >95% |
SEO Keyword Matrix
Core Keywords:
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Long-Tail Keywords:
"CDK4/6 inhibitor intermediate custom synthesis"
"Platinum chemotherapy potentiation ligand supplier"
"cGMP-grade CAS 24867-26-3 manufacturer"
Compliance Statements
? EINECS Status: Not listed (verified via ECHA database)
? REACH Progress: Under consortium registration (SIEF member ID: CHEM-2024-XXXXX)
? cGMP Compliance: ICH Q7 API intermediate standards (COA includes residual solvents/heavy metals testing)
? Analytical Support: Full documentation provided (HPLC, 1H/13C NMR, HRMS)
Company Profile Introduction
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China- Since: 2004-04-13
- Address: No. 10 Zhongxing Road, Xianpu Chemical Park, Liyang City, Changzhou City, Jiangsu Province, China