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Postion:Product Catalog >17β-hydroxy Exemestane
17β-hydroxy Exemestane
  • 17β-hydroxy Exemestane

17β-hydroxy Exemestane NEW

Price $658
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-04-30

Product Details

Product Name: 17β-hydroxy Exemestane CAS No.: 122370-91-6
Supply Ability: 10g Release date: 2025/04/30

Product Introduction

Bioactivity

Name17β-hydroxy Exemestane
Description17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationChloroform : Slightly soluble, Heating is recommended.
Methanol : Slightly soluble, Heating is recommended.
Keywords17β hydroxy Exemestane | 17b-hydroxy Exemestane | 17β-hydroxy Exemestane | 17beta-hydroxy Exemestane | 17βhydroxy Exemestane

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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