α-Synuclein inhibitor 8 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: α-Synuclein inhibitor 8 | CAS No.: 2883627-64-1 |
| Supply Ability: 10g | Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | α-Synuclein inhibitor 8 |
| Description | α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 μM, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects in damaged neurons and symptomatic improvement in Parkinson's disease (PD)-like models. The compound also exhibits high antioxidant activity and low cytotoxicity [1]. |
| In vitro | α-Synuclein inhibitor 8 (Compound 2ee) inhibits α-Synuclein aggregation dose-dependently (0-100 μM; 0-96 h) [1], disassembling mature fibrils into soluble proteins and some short insoluble fibers at 100 μM and 48 h [1]. It increases reactive oxygen species scavenging rate dose-dependently (1-1000 μM; 0.5 h or 24 h) and shows low cytotoxicity in H4 and SH-SY5Y cells, with viability over 80% [1]. At 10 μM for 38 h, α-Synuclein inhibitor 8 inhibits α-Synuclein aggregation and inclusion body formation in H4 cells [1]. |
| In vivo | Compound 2ee (α-Synuclein inhibitor 8), administered at a single dose of 0.9 μg/μL via intravenous injection, significantly ameliorated symptoms such as reduced grip strength, limb rigidity, and impaired balance in a Parkinson's disease (PD) C57 mouse model. Furthermore, α-Synuclein inhibitor 8 demonstrated a neuroprotective effect on the caudate putamen (CPu) and substantia nigra pars reticulata (SNr) within the brains of these Parkinson's disease C57 mouse models [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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