Product Information

• Product Code: I042016

• English Name: Indomethacin Sorbitol Ester 1:Primoryl Hydroxyl

• English Alias: (2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

• CAS No.: Not provided

• Molecular Formula: C??H??ClNO?

• Molecular Weight: 521.94

Advantages

• As an ester derivative of indomethacin and sorbitol, it combines the anti-inflammatory activity of indomethacin with the hydrophilicity of sorbitol, potentially improving the water solubility and bioavailability of the parent drug.

• The structure contains polyhydroxyl functional groups, which can be used as a novel prodrug or excipient for formulation development, providing more possibilities for drug delivery systems.

Applications

• Pharmaceutical Formulation R&D: Used to develop sustained-release or targeted formulations of indomethacin, regulating drug release rate through esterification modification to reduce gastrointestinal irritation.

• Prodrug Research: As a prodrug candidate, study its hydrolytic metabolic pathway and activity conversion in vivo to optimize pharmacokinetic properties.

• Excipient Compatibility Study: Evaluate its compatibility with other drug components as a functional excipient for (compound formulation) development.

Background Description

Research Status

• Synthesis Process: Currently mainly prepared by esterification reaction, with research focusing on optimizing reaction conditions (such as catalyst, temperature) to improve yield and purity.

• Efficacy Research: In vitro experiments show that some derivatives have anti-inflammatory activity comparable to indomethacin, but their in vivo metabolic mechanisms (such as ester bond hydrolysis rate) still need further verification.

• Formulation Application: Preliminary studies indicate that such esters can achieve controlled release through solid dispersion or microsphere formulations, and related dosage forms are in the preclinical evaluation stage.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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