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| | N-Acetyl-L-cysteine ethyl ester Basic information |
| Product Name: | N-Acetyl-L-cysteine ethyl ester | | Synonyms: | N-Acetyl-L-cysteine ethyl ester;L-Cysteine, N-acetyl-, ethyl ester;N-Acetylcysteine ethylester;(R)-ethyl 2-acetaMido-3-Mercaptopropanoate;(R)-Methyl 2-acetaMido-3-Mercaptopropanoate;-Ethyl 2-acetamido-3-mercaptopropanoate;ethyl (2R)-2-acetamido-3-sulfanylpropanoate;Acetylcysteine Impurity H | | CAS: | 59587-09-6 | | MF: | C7H13NO3S | | MW: | 191.25 | | EINECS: | 000-000-0 | | Product Categories: | 59587-09-6 | | Mol File: | 59587-09-6.mol |  |
| | N-Acetyl-L-cysteine ethyl ester Chemical Properties |
| Melting point | 44.1-44.5 °C | | Boiling point | 337.6±32.0 °C(Predicted) | | density | 1.138±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 9.17±0.10(Predicted) | | color | White to off-white |
| | N-Acetyl-L-cysteine ethyl ester Usage And Synthesis |
| Description | N-acetyl-L-Cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC; ). It has enhanced cell permeability in isolated perfused rat liver compared to NAC. N-acetyl-L-Cysteine ethyl ester (1 mM) prevents tert-butyl hydroperoxide-induced formation of methemoglobin in isolated human red blood cells. It increases glutathione levels in rat liver, kidney, heart, testis, and brain when administered at a dose of 50 mg/kg twice per day for two weeks. N-acetyl-L-Cysteine ethyl ester reduces increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels induced by paracetamol (acetaminophen; ) in rats. | | Uses | N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1]. | | References | [1] Daniela Giustarini, et al. N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential. Biochem Pharmacol. 2012 Dec 1;84(11):1522-33. DOI:10.1016/j.bcp.2012.09.010 |
| | N-Acetyl-L-cysteine ethyl ester Preparation Products And Raw materials |
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