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| Products Intro: |
Product Name:Mal-PEG1-Val-Cit-PAB-PNP
CAS:2249935-92-8
Purity:98% HPLC Package:10MG;25MG;50MG;100MG;1G;5G
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Mal-PEG1-Val-Cit-PAB-PNP manufacturers
- Mal-PEG1-Val-Cit-PAB-PNP
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- $0.00 / 100mg
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2025-06-07
- CAS:2249935-92-8
- Min. Order: 100mg
- Purity: >98.00%
- Supply Ability: 100mg
- Mal-PEG1-Val-Cit-PAB-PNP
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- $1.10 / 1g
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2022-07-16
- CAS:2249935-92-8
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | Mal-PEG1-Val-Cit-PAB-PNP Basic information |
| Product Name: | Mal-PEG1-Val-Cit-PAB-PNP | | Synonyms: | Mal-PEG1-Val-Cit-PAB-PNP;Mal-PEG1-Val-Cit-PAB-PNP ISO 9001：2015 REACH;L-Ornithinamide, N-[3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- | | CAS: | 2249935-92-8 | | MF: | C34H41N7O12 | | MW: | 739.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2249935-92-8.mol |  |
| | Mal-PEG1-Val-Cit-PAB-PNP Chemical Properties |
| Boiling point | 1039.5±65.0 °C(Predicted) | | density | 1.366±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DMF | | pka | 13.24±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | Mal-PEG1-Val-Cit-PAB-PNP Usage And Synthesis |
| Description | Mal-PEG1-Val-Cit-PAB-PNP is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups at pH 6.5 to 7.5. PNP is a good leaving group. | | Uses | Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | IC 50 | Protease Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Mal-PEG1-Val-Cit-PAB-PNP Preparation Products And Raw materials |
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