| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Lenalidomide-PEG1-azide
CAS:2185795-67-7
Package:2mg/RMB 1150
|
Lenalidomide-PEG1-azide manufacturers
|
| | Lenalidomide-PEG1-azide Basic information |
| | Lenalidomide-PEG1-azide Chemical Properties |
| solubility | DMSO : 100 mg/mL (258.83 mM; Need ultrasonic) | | form | Solid | | color | Off-white to light yellow |
| | Lenalidomide-PEG1-azide Usage And Synthesis |
| Uses | Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136)[1]. Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-PEG1-azide can be used to design a PROTAC BRD4 Degrader-2 [1]. | | References | [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. |
| | Lenalidomide-PEG1-azide Preparation Products And Raw materials |
|