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ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic acids >3-FLUORO-4-HYDROXYPHENYLACETIC ACID

3-FLUORO-4-HYDROXYPHENYLACETIC ACID

3-FLUORO-4-HYDROXYPHENYLACETIC ACID Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +8613336195806
Email: sales@capot.com
Products Intro: Product Name:3-Fluoro-4-hydroxyphenylacetic acid
CAS:458-09-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:3-Fluoro-4-hydroxyphenylacetic acid
CAS:458-09-3
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-69724
Company Name: CONIER CHEM AND PHARMA LIMITED
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Email: sales@conier.com
Products Intro: Product Name:3-fluoro-4-hydroxyphenylacetic acid
CAS:458-09-3
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
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Products Intro: Product Name: 3-FLUORO-4-HYDROXYPHENYLACETIC ACID
CAS: 458-09-3
Purity:97%-99% Package:1KG;9.8USD
Company Name: Fuxin Pharmaceutical
Tel: +86-021-021-50872116 +8613122107989
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Products Intro: Product Name:3-Fluoro-4-hydroxyphenylacetic acid
CAS:458-09-3
Purity:99% Package:1kg; 25kg; or larger package as required Remarks:pharmaceutical intermediates;Chemical Intermediate

3-FLUORO-4-HYDROXYPHENYLACETIC ACID manufacturers

3-FLUORO-4-HYDROXYPHENYLACETIC ACID Basic information
Product Name:3-FLUORO-4-HYDROXYPHENYLACETIC ACID
Synonyms:3-FLUORO-4-HYDROXYPHENYLACETIC ACID;4-(Carboxymethyl)-2-fluorophenol, (3-Fluoro-4-hydroxyphenyl)acetic acid;4-(Carboxymethyl)-2-fluorophenol;2-(3-fluoro-4-hydroxyphenyl)acetic acid;3-Fluoro-4-hydroxybenzeneacetic acid;3-Fluoro-4-hydroxyphenylacetic acid,98%;3-Fluoro-4-HydroxyphenylaceticAci;Benzeneacetic acid, 3-fluoro-4-hydroxy-
CAS:458-09-3
MF:C8H7FO3
MW:170.14
EINECS:207-275-8
Product Categories:Fluorine series;Carbonyl Compounds;Aromatic Phenylacetic Acids and Derivatives;C8;Carboxylic Acids
Mol File:458-09-3.mol
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Structure
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Chemical Properties
Melting point 132-134 °C (lit.)
Boiling point 320.3±27.0 °C(Predicted)
density 1.423±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form Crystalline Powder
pka4.30±0.10(Predicted)
color White to beige
CAS DataBase Reference458-09-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29182900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Usage And Synthesis
Chemical PropertiesWhite to beige crystalline powder
Synthesis
3-Fluoro-4-methoxyphenylacetic acid

452-14-2

3-FLUORO-4-HYDROXYPHENYLACETIC ACID

458-09-3

General procedure for the synthesis of 3-fluoro-4-hydroxyphenylacetic acid from 3-fluoro-4-methoxyphenylacetic acid: Aluminum chloride (42.8 g, 0.32 mol) was slowly added to 500 mL of toluene solution containing 3-fluoro-4-methoxyphenylacetic acid (45 g, 0.245 mol), and the temperature of the reaction was controlled to be no more than 25 °C. Subsequently, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, 260 mL of 10% hydrochloric acid was added to the cooled solution. The precipitate was collected by filtration and the filtrate was extracted twice with 75 mL of 1,2-dichloroethane. The organic extracts were combined and washed sequentially with 5% sodium hydroxide solution and water. The alkaline washings were combined with the previously collected precipitate and filtered through activated carbon after adjusting the pH to 12 with 5% sodium hydroxide solution. The filtrate was acidified with 50% sulfuric acid and the resulting oil was extracted with ether. The organic phase was dried and the solvent was evaporated to give 3-fluoro-4-hydroxyphenylacetic acid in a yield of 25 g (62% yield). The melting point of the product was 109-111 °C. Mass spectrum (ESI) m/z (relative abundance): 193.0 [M + Na]+.

Purification MethodsCrystallise the acid from water. [Beilstein 10 III 440.]
References[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Chemische Berichte, 1952, vol. 85, p. 577,580
[4] DRP/DRBP Org.Chem.,
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Preparation Products And Raw materials
Raw materials3-Fluoro-4-methoxyphenylacetic acid-->Aluminum chloride-->Hydrochloric acid
Tag:3-FLUORO-4-HYDROXYPHENYLACETIC ACID(458-09-3) Related Product Information
3'-Fluoro-4'-hydroxyacetophenone 3-FLUORO-4-(TRIFLUOROMETHOXY)PHENYLACETIC ACID 2,3-DIFLUORO-4-METHOXYPHENYLACETIC ACID 3,5-DIFLUORO-4-METHOXYPHENYLACETIC ACID 3-FLUORO-4-HYDROXYPHENYLACETIC ACID 3-FLUORO-4-METHOXYPHENYLACETIC ACID 4-fluoro-à-hydroxyphenylacetic acid 2-Fluoro-4-hydroxyphenylacetic acid ETHYL 3-FLUORO-4-METHOXYBENZOYLFORMATE AMINO-(3-FLUORO-4-METHOXY-PHENYL)-ACETIC ACID Ethyl Difluoro-(3-fluoro-4-methoxyphenyl)acetate 2-Fluoro-5-hydroxyphenylacetic acid 4-Fluoro-3-hydroxyphenylacetic acid (2S)-2-AMINO-2-[3-FLUORO-4-(PHENYLMETHOXY)PHENYL]PROPANOIC ACID [3-(chlorosulfonyl)-5-fluoro-4-methoxyphenyl]acetic acid (2S)-2-AMINO-2-(3,5-DIFLUORO-4-METHOXYPHENYL)PROPANOIC ACID (2S)-2-AMINO-2-(3-FLUORO-4-[(4-NITROPHENYL)METHOXY]PHENYL)PROPANOIC ACID (2R)-2-AMINO-2-(3,5-DIFLUORO-4-METHOXYPHENYL)PROPANOIC ACID

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