| Company Name: |
Hubei Jusheng Technology Co.,Ltd. |
| Tel: |
18871490254 |
| Email: |
linda@hubeijusheng.com |
| Products Intro: |
Product Name:(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenoxy]oxane-2-carboxylic acid
CAS:227466-72-0
Purity:0.99 Package:5KG;1KG Remarks:C27H28O12
|
|
|
|
|
|
| | Curcumin β-D-Glucuronide Basic information |
| Product Name: | Curcumin β-D-Glucuronide | | Synonyms: | 4-[(1E,6E)-7-(4-Hydroxy-3-Methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid;Curcumin β-D-Glucuronide;Curcumin-4-O-beta-D-glucuronide min. 85%;Curcumin β-D-Glucuronide
DISCONTINUED. Please see C838505.;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenoxy]oxane-2-carboxylicaci;Curcumin b-D-Glucuronide;Curcumin-4-O-β-D-glucuronide;β-D-Glucopyranosiduronic acid, 4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-methoxyphenyl | | CAS: | 227466-72-0 | | MF: | C27H28O12 | | MW: | 544.5 | | EINECS: | | | Product Categories: | Aromatics, Inhibitors, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals | | Mol File: | 227466-72-0.mol |  |
| | Curcumin β-D-Glucuronide Chemical Properties |
| Boiling point | 838.7±65.0 °C(Predicted) | | density | 1.470±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | powder | | pka | 2.78±0.70(Predicted) | | color | Orange |
| | Curcumin β-D-Glucuronide Usage And Synthesis |
| Chemical Properties | Dark Orange Solid | | Uses | Curcumin β-D-Glucuronide is a metabolite of Curcumin (C838510) in hepatic tissue and portal blood. | | Definition | ChEBI: Curcumin glucuronide is a diarylheptanoid. | | Biological Activity | Studies have demonstrated th at Curcumin β-D-glucuronide exhibits anticancer properties in mouse tumor models and human metastatic colorectal cancer cell lines by promoting apoptosis. Additionally, it has shown potential as a colon cancer prevention agent through metabolism by r at liver microsomes. This compound also possesses anti-inflammatory attributes attributed to its ability to inhibit prostaglandin E2 (PGE2) levels in humans. | | in vivo | Curcumin-β-D-glucuronide (90 mg/kg; i.p. thrice a week for 3 weeks) exhibit potent anti-tumor effects on KRASm/TP53w HCT116 xenograft model[1]. | Animal Model: | Female BALB/c/AnNCr j‐nu/nude mice (6 weeks) were transplanted KRASm/TP53w HCT116 cells[1] | | Dosage: | 90 mg/kg | | Administration: | I.p. thrice a week for 3 weeks | | Result: | Suppressed tumor growth by 38%.
Did not show a negative impact on body weight.
Attenuated NF‐κB activity.
|
|
| | Curcumin β-D-Glucuronide Preparation Products And Raw materials |
|