| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HDAC-IN-43
CAS:1809163-24-3
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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Butanamide, N-hydroxy-4-[3-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]phenoxy]- manufacturers
- HDAC-IN-43
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- $2500.00 / 100mg
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2025-07-17
- CAS:1809163-24-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Butanamide, N-hydroxy-4-[3-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]phenoxy]- Basic information |
| | Butanamide, N-hydroxy-4-[3-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]phenoxy]- Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | pka | 9.32±0.20(Predicted) |
| | Butanamide, N-hydroxy-4-[3-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]phenoxy]- Usage And Synthesis |
| Uses | HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1]. | | IC 50 | HDAC6: 24 nM (IC50); HDAC3: 45 nM (IC50); HDAC1: 82 nM (IC50); HDAC10: 182 nM (IC50); HDAC2: 358 nM (IC50); HDAC8: 1441 nM (IC50); HDAC11: 9061 nM (IC50) | | References | [1] Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724. DOI:10.1016/j.bioorg.2020.103724 |
| | Butanamide, N-hydroxy-4-[3-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]phenoxy]- Preparation Products And Raw materials |
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