- 4-Fluorobenzaldehyde
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- $100.00 / 25kg
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2025-07-07
- CAS:459-57-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 50000KG/month
- 4-Fluorobenzaldehyde
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- $1.00 / 25KG
-
2025-06-24
- CAS:459-57-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | 4-Fluorobenzaldehyde Basic information |
| | 4-Fluorobenzaldehyde Chemical Properties |
| Melting point | -10 °C (lit.) | | Boiling point | 181 °C/758 mmHg (lit.) | | density | 1.157 g/mL at 25 °C (lit.) | | vapor pressure | 19 hPa (70 °C) | | refractive index | n20/D 1.521(lit.) | | Fp | 134 °F | | storage temp. | Store below +30°C. | | solubility | Chloroform, Methanol | | form | Liquid | | Specific Gravity | 1.157 | | color | Clear colorless to yellow | | Water Solubility | IMMISCIBLE | | Sensitive | Air Sensitive | | BRN | 385857 | | Stability: | Air Sensitive | | InChIKey | UOQXIWFBQSVDPP-UHFFFAOYSA-N | | CAS DataBase Reference | 459-57-4(CAS DataBase Reference) | | NIST Chemistry Reference | Benzaldehyde, 4-fluoro-(459-57-4) | | EPA Substance Registry System | Benzaldehyde, 4-fluoro- (459-57-4) |
| Hazard Codes | Xi,F | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39-36/37/39-27 | | RIDADR | UN 1989 3/PG 3 | | WGK Germany | 2 | | F | 9-23 | | Hazard Note | Flammable | | TSCA | T | | HazardClass | 3.2 | | PackingGroup | III | | HS Code | 29130000 |
| | 4-Fluorobenzaldehyde Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow liquid | | Uses | Usually used in the preparation of pyrazolopyridine UR-13756. | | Uses | 4-Fluorobenzaldehyde is a fluorinated benzaldehyde with inhibitory activity of mushroom tyrosinase. 4-Fluorobenzaldehyde is commonly used as a synthetic intermediate in the preparation of pharmaceutic
al compounds. | | Uses | 4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds. | | Synthesis | 4-Fluorobenzaldehyde is produced by a commercially feasible process. The process comprises heating a mixture of fluorobenzene and a strong Lewis acid with dissolved hydrogen halide in an atmosphere of carbon monoxide at about 45 to about 100° C. and at a total pressure of about 150 psig up to the maximum pressure rating of the reactor. Formed is a reaction mass containing a Lewis acid complex of 4-fluorobenzaldehyde and at least a halobis(fluorophenyl)methane by-product. The complex is broken by quenching the reaction mass with a Lewis acid-solvating liquid to liberate 4-fluorobenzaldehyde. By-product halobis(fluorophenyl)methane is converted to di(fluorophenyl)methanol to avoid potential corrosion problems and formation of light-sensitive color bodies in the recovered 4-fluorobenzaldehyde.
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| | 4-Fluorobenzaldehyde Preparation Products And Raw materials |
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