| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:KS-133
CAS:2724212-01-3
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
|
| Tel: |
0571-87213919 17306812703 |
| Email: |
3007955328@qq.com |
| Products Intro: |
Product Name:KS-133
CAS:2724212-01-3
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
|
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| | KS-133 Chemical Properties |
| Boiling point | 1784.8±65.0 °C(predicted) | | density | 1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 9.89±0.15(predicted) | | Sequence | Ac-Cys-Pro-Pro-Tyr-Leu-Pro-cyclo(Lys-Tyr-Leu-Cys-Asp)-Leu-Ile-NH2 (disulfide bridge:Cys1-Cys10) |
| | KS-133 Usage And Synthesis |
| Uses | KS-133 is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 plays an important role in schizophrenia research[1]. | | References | [1] Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587. DOI:10.3389/fphar.2021.751587 |
| | KS-133 Preparation Products And Raw materials |
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