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| | 2-Methyl-1,3-thiazole-4-carboxylic acid Basic information |
| | 2-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties |
| Melting point | 148 °C | | Boiling point | 301.2±15.0 °C(Predicted) | | density | 1.418±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | powder to crystal | | pka | 4.28±0.10(Predicted) | | color | White to Light yellow | | CAS DataBase Reference | 35272-15-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 2 | | HazardClass | IRRITANT | | HS Code | 29341000 |
| | 2-Methyl-1,3-thiazole-4-carboxylic acid Usage And Synthesis |
| Chemical Properties | White to orange to tan solid | | Synthesis | The general procedure for the synthesis of 2-methyl-4-thiazolecarboxylic acid using ethyl 2-methylthiazole-4-carboxylate as starting material is as follows:
1. dissolve ethyl 2-methylthiazole-4-carboxylate in tetrahydrofuran (THF).
2. add 10% (w/v) aqueous solution of potassium hydroxide (KOH) to the above solution.
3. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete disappearance of the raw material.
4. pH of the reaction solution was adjusted to 4 with 1 M hydrochloric acid (HCl).
5. The reaction solution was extracted with ethyl acetate (EtOAc). 6.
6. The organic phase was dried with anhydrous magnesium sulfate (MgSO?).
7. The organic phase was concentrated to give the target product 2-methyl-4-thiazolecarboxylic acid. | | References | [1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 31
[4] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 6, p. 703 - 709
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23 |
| | 2-Methyl-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials |
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