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| | ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Basic information |
| Product Name: | ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE | | Synonyms: | BUTTPARK 10\01-32;ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE;ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE;4-HYDROXY-6-TRIFLUOROMETHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-(Ethoxycarbonyl)-6-(trifluoromethyl)quinolin-4-ol, 3-(Ethoxycarbonyl)-4-hydroxy-6-(trifluoromethyl)quinoline;4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylic acid ethyl ester;ethyl 4-oxo-6-(trifluoromethyl)-1H-quinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-hydroxy-6-(trifluoromethyl)-, ethyl ester | | CAS: | 26893-12-9 | | MF: | C13H10F3NO3 | | MW: | 285.22 | | EINECS: | | | Product Categories: | Acids and Derivatives;Heterocycles | | Mol File: | 26893-12-9.mol |  |
| | ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Chemical Properties |
| Melting point | 336(dec.) | | Boiling point | 343.5±37.0 °C(Predicted) | | density | 1.404±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 1.84±0.50(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933499090 |
| | ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Usage And Synthesis |
| Synthesis | GENERAL METHODS: Polyphosphoric acid (PPA) (2 eq. by weight) was mixed with Intermediate 1 (40 mmol), followed by the addition of phosphoryl chloride (POCl3) (10 mmol). The reaction mixture was heated to 75 °C and maintained for 8 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was quenched by slowly pouring it into 10% sodium hydroxide solution in an ice bath while adjusting the pH to about 7. The resulting solid was separated by filtration, dried, and washed with ether (3 x 20 mL) to afford ethyl 4-hydroxy-6-trifluoromethylquinoline-3-carboxylate in good yield. | | References | [1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[2] Organic Process Research and Development, 2014, vol. 18, # 11, p. 1482 - 1491
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 6, p. 1577 - 1580 |
| | ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials |
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