- SC66
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- $40.00 / 5mg
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2025-07-19
- CAS:871361-88-5
- Min. Order:
- Purity: 99.6%
- Supply Ability: 10g
- SC 66
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- $1.00 / 1g
-
2019-12-24
- CAS:871361-88-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| Product Name: | SC 66 | | Synonyms: | SC 66;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA | | CAS: | 871361-88-5 | | MF: | C18H16N2O | | MW: | 276.33 | | EINECS: | | | Product Categories: | | | Mol File: | 871361-88-5.mol |  |
| | SC 66 Chemical Properties |
| storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: ≥5mg/mL (warmed) | | form | powder | | color | faint yellow to dark yellow |
| | SC 66 Usage And Synthesis |
| Description | Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth. | | Uses | SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance. | | in vivo | To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm3, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group[1]. | | storage | -20°C |
| | SC 66 Preparation Products And Raw materials |
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