MK 3207 hydrochloride manufacturers
- MK-3207 HCl
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- $1.00 / 1g
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2020-01-13
- CAS:957116-20-0
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1ton
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| | MK 3207 hydrochloride Basic information |
| Product Name: | MK 3207 hydrochloride | | Synonyms: | (8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride;MK 3207 hydrochloride;MK-3207 HCl salt;MK3207 HCl;6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, hydrochloride;MK3207 HYDROCHLORIDE;MK 3207 HYDROCHLORIDE;MK-3207;2-((R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)-N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide hydrochloride;CS-549 | | CAS: | 957116-20-0 | | MF: | C31H30ClF2N5O3 | | MW: | 594.06 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors | | Mol File: | 957116-20-0.mol |  |
| | MK 3207 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | Off-white to pink |
| | MK 3207 hydrochloride Usage And Synthesis |
| Uses | MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3. | | Biological Activity | MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, respectively, with high selectivity for human AM1, AM2, CTR, and AMY3. Phase 2. | | in vivo | MK-3207 is CNS-penetrant and therefore significantly engaging central receptors. After an oral dose of 10 mg/kg MK-3207, the CSF/plasma ratio is 2 to 3%[1]. | | References | [1] Salvatore CA, et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DOI:10.1124/jpet.109.163816 |
| | MK 3207 hydrochloride Preparation Products And Raw materials |
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