| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CP-544439
CAS:230954-09-3
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CP-544439
CAS:230954-09-3
Purity:98.11% Package:1mg/RMB 1980;5mg/RMB 4920;10mg/RMB 7130
|
CP-544439 manufacturers
- CP-544439
-
- $293.00 / 1mg
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2024-11-11
- CAS:230954-09-3
- Min. Order:
- Purity: 98.11%
- Supply Ability: 10g
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| | CP-544439 Basic information |
| Product Name: | CP-544439 | | Synonyms: | CP-544439;2H-Pyran-4-carboxamide, 4-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]tetrahydro-N-hydroxy-;UNII-516DO4KL5R;CP 544439,CP544439 | | CAS: | 230954-09-3 | | MF: | C18H19FN2O6S | | MW: | 410.42 | | EINECS: | | | Product Categories: | | | Mol File: | 230954-09-3.mol |  |
| | CP-544439 Chemical Properties |
| | CP-544439 Usage And Synthesis |
| Uses | CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2]. | | in vivo | In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1]. | | IC 50 | MMP-13: 0.75 nM (IC50); MMP-12: 0.24 nM (IC50); MMP-1: 420 nM (IC50); MMP-2: 1.6 nM (IC50); MMP-3: 16 nM (IC50); MMP-8: 1.4 nM (IC50); MMP-9: 12 nM (IC50); MMP-14: 7.4 nM (IC50) | | References | [1] Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profil DOI:10.1124/dmd.108.022566
[2] Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. DOI:10.1016/j.bmcl.2004.04.083 |
| | CP-544439 Preparation Products And Raw materials |
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