| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10592
CAS:685139-10-0
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Dalian Meilun Biotech Co., Ltd.
|
| Tel: |
0411-62910999 13889544652 |
| Email: |
sales@meilune.com |
| Products Intro: |
Product Name:CAY-10592
CAS:685139-10-0
Purity:>98%,BR Package:1MG Remarks:MB6148
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10592
CAS:685139-10-0
Purity:98% Package:1G;10G;100G Remarks:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPA
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CAY10592 manufacturers
- CAY10592
-
- $0.00 / 1mg
-
2025-07-30
- CAS:685139-10-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CAY10592 Basic information |
| Product Name: | CAY10592 | | Synonyms: | 2-[4-[[3,3-BIS(4-BROMOPHENYL)-2-PROPEN-1-YL]THIO]-2-CHLOROPHENOXY]-ACETIC ACID;CAY10592;2-[4-[3,3-bis(4-bromophenyl)prop-2-enylsulfanyl]-2-chlorophenoxy]acetic acid;CAY10592 Exclusive;NQIYGYDPRBEUAZ-UHFFFAOYSA-N;CAY10592,CAY-10592;Acetic acid, 2-[4-[[3,3-bis(4-bromophenyl)-2-propen-1-yl]thio]-2-chlorophenoxy]-;PPARδ agonist 10 | | CAS: | 685139-10-0 | | MF: | C23H17Br2ClO3S | | MW: | 568.71 | | EINECS: | | | Product Categories: | | | Mol File: | 685139-10-0.mol |  |
| | CAY10592 Chemical Properties |
| Boiling point | 656.7±55.0 °C(Predicted) | | density | 1.69±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 3.02±0.10(Predicted) |
| | CAY10592 Usage And Synthesis |
| Description | Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) in a fatty acid oxidation assay of rat L6 muscle cells with desirable oral pharmacokinetic properties. In a transactivation assay using human PPAR receptors, CAY10592 acts as a selective partial PPARδ agonist (EC50 = 53 nM) with no effect on PPARα or PPARγ activity up to 30 μM. Chronic treatment of high fat fed ApoB100/CETP-transgenic mice with CAY10592 at a dose of 20 mg/kg increases HDL levels, decreases LDL and TG levels, and improves insulin sensitivity. |
| | CAY10592 Preparation Products And Raw materials |
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