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| | 3-Hydroxy-4-methoxybenzyl alcohol Basic information |
| | 3-Hydroxy-4-methoxybenzyl alcohol Chemical Properties |
| Melting point | 135-137 °C (lit.) | | Boiling point | 315.8±27.0 °C(Predicted) | | density | 1.226±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 9.75±0.10(Predicted) | | color | White to Almost white | | BRN | 1867860 | | CAS DataBase Reference | 4383-06-6(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Hydroxy-4-methoxybenzyl alcohol(4383-06-6) |
| | 3-Hydroxy-4-methoxybenzyl alcohol Usage And Synthesis |
| Chemical Properties | White crystalline | | Uses | 3-Hydroxy-4-methoxybenzyl alcohol was used in preparation of 2-hydroxymethyl-5-methoxy-2,5-cyclohexadiene-1,4-dione by oxidation with Fremy′s salt. | | Synthesis | 3-Hydroxy-4-methoxybenzyl alcohol is synthesised using isovanillin as raw material by chemical reaction. The specific synthesis steps are as follows:
In a round-bottom flask equipped with magnetic stirrer was added 15 sodium borohydride (0.2mmol; 0.01g) to the solution of 9 1 (0.2mmol; 0.03g) prepared in ethanol (1mL). The mixture was stirred at room temperature for 30min. The consumption of all starting material was detected by thin layer chromatography (TLC); the solvent was evaporated under reduced pressure. Subsequently, 10mL of saturated NaCl solution was added and then extracted with ethyl acetate (3×10mL). The organic phase was dried over anhydrous MgSO4, filtered and evaporated, providing 0.03g of colorless oil, 90% yield of 3-Hydroxy-4-methoxybenzyl alcohol.
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| | 3-Hydroxy-4-methoxybenzyl alcohol Preparation Products And Raw materials |
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