ATN-161 manufacturers
- ATN-161
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- $3700.00 / 100mg
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2025-07-17
- CAS:262438-43-7
- Min. Order:
- Purity:
- Supply Ability: 10g
- ATN-161
-
- $3700.00 / 100mg
-
2024-10-28
- CAS:262438-43-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | ATN-161 Basic information |
| Product Name: | ATN-161 | | Synonyms: | ATN-161;ATN-161(free base);ATN161; ATN 161;(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide;ATN-161 (Ac-PHSCN-NH2);L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-;ATN-161 >=98% (HPLC);AC-PHSCN-NH2 | | CAS: | 262438-43-7 | | MF: | C23H35N9O8S | | MW: | 597.64 | | EINECS: | | | Product Categories: | | | Mol File: | 262438-43-7.mol |  |
| | ATN-161 Chemical Properties |
| Boiling point | 1297.2±65.0 °C(Predicted) | | density | 1.443±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Water:7.5(Max Conc. mg/mL);12.56(Max Conc. mM) | | pka | 9.14±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble to 2 mg/ml in water |
| | ATN-161 Usage And Synthesis |
| Uses | ATN 161 is an α5β1 integrin inhibitor that has advanced to phase II clinical trials to treat solid tumors. | | Biological Activity | ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin th at inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity. | | in vivo | The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density[1]. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564[2]. | | storage | Store at -20°C |
| | ATN-161 Preparation Products And Raw materials |
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