| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CDK1-IN-1
CAS:2761858-59-5
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- manufacturers
- CDK1-IN-1
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- $1520.00 / 25mg
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2025-07-18
- CAS:2761858-59-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- Basic information |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- Chemical Properties |
| density | 1.31±0.1 g/cm3(Predicted) | | form | Solid | | pka | 12.03±0.50(Predicted) | | color | Yellow to orange |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- Usage And Synthesis |
| Uses | CDK1-IN-1 is a potent CDK1 inhibitor (CDK1/CycB IC50=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent[1]. | | IC 50 | CDK1/cycB: 161.2 nM (IC50) | | References | [1] Elgiushy HR, et al. Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105646. DOI:10.1016/j.bioorg.2022.105646
[2] Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. DOI:10.1021/acs.jpclett.0c03119 |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- Preparation Products And Raw materials |
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