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114798-36-6 Basic information More..
Product Name:Losartan Carboxaldehyde
Synonyms:2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;DUP 167;EXP 3179;Losartan Carboxaldehyde Discontinued see product # L470505;Losartan Carboxaldehyde;2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;Losartan Carboxaldehyde-d3;Losartan EP IMpurity K (LosaratnCarboxaldehyde)
CAS:114798-36-6
MF:C22H21ClN6O
MW:420.89
EINECS:
Mol File:114798-36-6.mol
114798-36-6

Use

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

Losartan Carboxaldehyde manufacturers

  • Losartan Carboxaldehyde
  • US $31.00-118.00 / mg
  • 2025-05-01
  • CAS:114798-36-6
  • Min. Order:
  • Purity: 99.10%
  • Supply Ability: 10g
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