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ChemicalBook >> CAS DataBase List >> SR 1903

SR 1903

SR 1903 price.
  • $37 - $249
  • Product name: SR 1903
  • CAS: 1414248-06-8
  • MF: C27H27F6N3O
  • MW: 523.52
  • EINECS:
  • MDL Number:
  • Synonyms:SR 1903;[1,1'-Biphenyl]-4-methanol, 2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-;2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol;1,1,1,3,3,3-Hexafluoro-2-(2'-methyl-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol;1,1,1,3,3,3-Hexafluoro-2-[4-[2-methyl-4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol
3 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerCayman Chemical
  • Product number28253
  • Product descriptionSR 1903
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28253
  • Product descriptionSR 1903
  • Packaging5mg
  • Price$134
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28253
  • Product descriptionSR 1903
  • Packaging10mg
  • Price$249
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 28253 SR 1903 1mg $37 2024-03-01 Buy
Cayman Chemical 28253 SR 1903 5mg $134 2024-03-01 Buy
Cayman Chemical 28253 SR 1903 10mg $249 2024-03-01 Buy

Properties

Boiling point :559.0±50.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :9.23±0.15(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.