Costunolide
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- $29 - $980
- Product name: Costunolide
- CAS: 553-21-9
- MF: C15H20O2
- MW: 232.32
- EINECS:
- MDL Number:MFCD00210262
- Synonyms:(3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE;COSTUNOLIDE;(e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone ;germacra-1(10),4,11(13)-trien-12-oicacid,6-alpha-hydroxy-,gamma-lactone,(e, ;Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-;CUSTUNOLIDE;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-;hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-
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Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- JR MediChem
- Labseeker
- Sigma-Aldrich
- TCI Chemical
- Tocris
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- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 1
- 250mg
- 10
- 1g
- 5g
- ManufacturerAK Scientific
- Product numberV1471
- Product descriptionCostunolide
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV1471
- Product descriptionCostunolide
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberV1471
- Product descriptionCostunolide
- Packaging25mg
- Price$219
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA496529
- Product descriptionCostunolide 98+%
- Packaging5mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA496529
- Product descriptionCostunolide 98+%
- Packaging10mg
- Price$43
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA496529
- Product descriptionCostunolide 98+%
- Packaging100mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA496529
- Product descriptionCostunolide 98+%
- Packaging250mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA496529
- Product descriptionCostunolide 98+%
- Packaging1g
- Price$482
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3327
- Product descriptionCostunolide
- Packaging10mg
- Price$84
- Updated2021-12-16
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- ManufacturerArctom
- Product numberAS023163
- Product descriptionCostunolide ≥98%
- Packaging5mg
- Price$33
- Updated2021-12-16
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- ManufacturerArctom
- Product numberCFN98928
- Product descriptionCostunolide ≥98%
- Packaging20mg
- Price$40
- Updated2021-12-16
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- ManufacturerArctom
- Product numberAS023163
- Product descriptionCostunolide ≥98%
- Packaging10mg
- Price$43
- Updated2021-12-16
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- ManufacturerArctom
- Product numberSY067309
- Product descriptionCostunolide,98%,fromAuckiandialappaDecne.
- Packaging10mg
- Price$68.18
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS023163
- Product descriptionCostunolide ≥98%
- Packaging100mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS023163
- Product descriptionCostunolide ≥98%
- Packaging250mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS023163
- Product descriptionCostunolide ≥98%
- Packaging1g
- Price$477
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | V1471 | Costunolide | 5mg | $72 | 2021-12-16 | Buy |
| AK Scientific | V1471 | Costunolide | 10mg | $108 | 2021-12-16 | Buy |
| AK Scientific | V1471 | Costunolide | 25mg | $219 | 2021-12-16 | Buy |
| Ambeed | A496529 | Costunolide 98+% | 5mg | $33 | 2021-12-16 | Buy |
| Ambeed | A496529 | Costunolide 98+% | 10mg | $43 | 2021-12-16 | Buy |
| Ambeed | A496529 | Costunolide 98+% | 100mg | $101 | 2021-12-16 | Buy |
| Ambeed | A496529 | Costunolide 98+% | 250mg | $200 | 2021-12-16 | Buy |
| Ambeed | A496529 | Costunolide 98+% | 1g | $482 | 2021-12-16 | Buy |
| ApexBio Technology | A3327 | Costunolide | 10mg | $84 | 2021-12-16 | Buy |
| Arctom | AS023163 | Costunolide ≥98% | 5mg | $33 | 2021-12-16 | Buy |
| Arctom | CFN98928 | Costunolide ≥98% | 20mg | $40 | 2021-12-16 | Buy |
| Arctom | AS023163 | Costunolide ≥98% | 10mg | $43 | 2021-12-16 | Buy |
| Arctom | SY067309 | Costunolide,98%,fromAuckiandialappaDecne. | 10mg | $68.18 | 2021-12-16 | Buy |
| Arctom | AS023163 | Costunolide ≥98% | 100mg | $100 | 2021-12-16 | Buy |
| Arctom | AS023163 | Costunolide ≥98% | 250mg | $198 | 2021-12-16 | Buy |
| Arctom | AS023163 | Costunolide ≥98% | 1g | $477 | 2021-12-16 | Buy |
Properties
Melting point :106-107 °C
Boiling point :385.4±42.0 °C(Predicted)
Density :1.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL (clear solution)
form :powder
color :white to beige
optical activity :[α]/D +110.0 to +130.0°, c =0.5 in chloroform-d
InChI :InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
InChIKey :HRYLQFBHBWLLLL-GRFSRWIASA-N
SMILES :O1C(=O)C(=C)[C@]2([H])CCC(C)=CCCC(C)=C[C@@]12[H] |t:10,15|
LogP :4.049 (est)
CAS DataBase Reference :553-21-9(CAS DataBase Reference)
NIST Chemistry Reference :Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9)
Boiling point :385.4±42.0 °C(Predicted)
Density :1.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL (clear solution)
form :powder
color :white to beige
optical activity :[α]/D +110.0 to +130.0°, c =0.5 in chloroform-d
InChI :InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
InChIKey :HRYLQFBHBWLLLL-GRFSRWIASA-N
SMILES :O1C(=O)C(=C)[C@]2([H])CCC(C)=CCCC(C)=C[C@@]12[H] |t:10,15|
LogP :4.049 (est)
CAS DataBase Reference :553-21-9(CAS DataBase Reference)
NIST Chemistry Reference :Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM). It also inhibits telomerase activity in NALM-6 cells.More related product prices
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Suppliers and manufacturers
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