AG 1478
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- $76.2 - $798
- Product name: AG 1478
- CAS: 175178-82-2
- MF: C16H14ClN3O2
- MW: 315.75
- EINECS:
- MDL Number:MFCD00270914
- Synonyms:NSC 669364;N-[3-CHLOROPHENYL]-6,7-DIMETHOXY-4-QUINAZOLINAMINE;N-(3-CHLOROPHENYL)-N-(6,7-DIMETHOXY-4-QUINAZOLINYL)AMINE;SU 5271;WHI-P 79;TYRPHOSTIN AG 1478;TYRPHOSTIN AG 1517;AG 1478
6 prices
Selected condition：
Brand
- AHH
- American Custom Chemicals Corporation
- Sigma-Aldrich
Package
- 1mg
- 5mg
- 0.025g
- 1G
- ManufacturerAHH
- Product numberMT-39714
- Product description4-(3-Bromoanilino)-6,7-dimethoxyquinazoline 98%
- Packaging0.025g
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001450
- Product descriptionAG 1478 95.00%
- Packaging1G
- Price$798
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberT4182
- Product descriptionTyrphostin AG 1478 ≥98%
- Packaging5mg
- Price$228
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberT4182
- Product descriptionTyrphostin AG 1478 ≥98%
- Packaging1mg
- Price$76.2
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number658552
- Product descriptionAG 1478
- Packaging5mg
- Price$187
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number658548
- Product descriptionInSolution? AG 1478
- Packaging1mg
- Price$113
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-39714 | 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline 98% | 0.025g | $230 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001450 | AG 1478 95.00% | 1G | $798 | 2021-12-16 | Buy |
| Sigma-Aldrich | T4182 | Tyrphostin AG 1478 ≥98% | 5mg | $228 | 2024-03-01 | Buy |
| Sigma-Aldrich | T4182 | Tyrphostin AG 1478 ≥98% | 1mg | $76.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 658552 | AG 1478 | 5mg | $187 | 2024-03-01 | Buy |
| Sigma-Aldrich | 658548 | InSolution? AG 1478 | 1mg | $113 | 2024-03-01 | Buy |
Properties
Melting point :180 - 183°C
storage temp. :2-8°C
solubility :0.1 M HCl: soluble <0.4 mg/mL
form :Pale yellow solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
storage temp. :2-8°C
solubility :0.1 M HCl: soluble <0.4 mg/mL
form :Pale yellow solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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Description
Tyrphostin AG 1478 is a tyrosine kinase inhibitor that has been demonstrated to be a selecetive and potent inhibitor of EGFR (Epidermal Growth Factor Receptor ) in a variety of cell lines with an IC50 of about 3 nM. In Rat-1 fibroblasts, Tyrphostin AG 1478 was demonstrated to downregulate EGF-stimulated DNA synthesis. The induction of p21/ip1/WAF1 and activation of EGF-dependent src-family kinase was noted to be blocked by Tyrphostin AG 1478 in the epidermoid carcinoma cell line A431. Additionally, a study utilizing early-weaned rats to study EGFR signaling and its role in mucosal cell proliferation, the administration of Tyrphostin AG 1478 was noted to decrease ERK phosphorylation without affecting p-Src and p-Akt. Tyrphostin AG 1478 was also noted to reduce measures of mitosis and DNA synthesis in this study. As EGFR is found to be overexpressed in various cancer cells, there may be research interest in compounds that inhibit EGFR, such as Tyrphostin AG 1478.More related product prices
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Suppliers and manufacturers
Hubei Jusheng Technology Co.,Ltd.
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
DAYANG CHEM (HANGZHOU) CO.,LTD
Amadis Chemical Company Limited
J & K SCIENTIFIC LTD.
Shanghai Paulshine Chemical Co., Ltd.
Jinan Trio PharmaTech Co., Ltd.
Spectrum Chemical Manufacturing Corp.