バルスポダール 価格 もっと(3)

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入
富士フイルム和光純薬株式會社(wako)	W01TOC4042	PSC 833	121584-18-7	1mg	￥95000	2024-03-01	購入
Sigma-Aldrich Japan	SML0572	≥98% (HPLC) Valspodar ≥98% (HPLC)	121584-18-7	5mg	￥38800	2024-03-01	購入
Sigma-Aldrich Japan	SML0572	≥98% (HPLC) Valspodar ≥98% (HPLC)	121584-18-7	25mg	￥154000	2024-03-01	購入

バルスポダール 化學(xué)特性,用途語,生産方法

効能

抗悪性腫瘍薬, P-糖タンパク質(zhì)阻害薬

説明

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [¹⁴C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

化學(xué)的特性

White Solid

使用

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

細胞毒性(Cytotoxicity)

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].

バルスポダール 上流と下流の製品情報

原材料

準(zhǔn)備製品

バルスポダール 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19654	58
Adachibio Inc.	+8108027837258	sales@adachibio.com	Japan	992	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32368	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9267	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

121584-18-7(バルスポダール)キーワード:

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• 121584-18-7
• Valspodar
• 3'-Keto-bmt(1)-Val(2)-cyclosporin a
• Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
• Sdz psc 833
• Sdz-psc-833
• Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]
• 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
• Valspodar(PSC-833,AMdray)
• 6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3- oxo-6-octenoic Acid]ccyclosporin D
• 6-[[R-(E)]-6,7-Didehydro-N,4-diMethyl-3-oxo-L-2-aMinooctanoic acid]-7-L-valinecyclosporin A
• AMdray
• Valpodar
• PSC833(Valspodar)
• Cyclosporin A,6-[(2S,4R,6E)-4-Methyl-2-(MethylaMino)-3-oxo-6-octenoic acid]-7-L-valine-
• Valspodar (PSC-833)
• [3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin
• 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
• PSC833 - Specific MDR1/P-gp Inhibitor
• Valspodar, >=98%
• CS-51
• PSC 833; PSC-833; PSC833
• Psc 833
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-6,9,18,24-Tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-enoyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,28-nonamethyl-33-[(2R,4E)-2-methylhex-4-enoyl]-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tris(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• Valspodar (PSC-833), P-glycoprotein inhibitor
• バルスポダール
• SDZ PSC-833
• アムドレイ
• バルポダル
• バルスポダル
• (4R)-N-メチル-3-オキソ-5-[(E)-1-プロペニル]シクロ(L-Leu-L-Val-Sar-N-メチル-L-Leu-L-Val-N-メチル-L-Leu-L-Ala-D-Ala-N-メチル-L-Leu-N-メチル-L-Leu-N-メチル-L-Val-)
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33R)-1,4,7,10,12,15,19,25,28-ノナメチル-33-[(2R,4E)-2-メチルヘキサ-4-エノイル]-6,9,18,24-テトラキス(2-メチルプロピル)-3,21,30-トリス(プロパン-2-イル)-1,4,7,10,13,16,19,22,25,28,31-ウンデカアザシクロトリトリアコンタン-2,5,8,11,14,17,20,23,26,29,32-ウンデカオン