cis-15-テトラコセン酸 化學特性,用途語,生産方法
外観
白色～黃色～黃赤色粉末～結晶
解説
ネルボン酸，ネルボンサン，脳のセレブロシドの一分畫である，ネルボンの構成脂肪酸として存在するほか，スフィンゴミエリン，血球糖脂質，アイザメの肝油などにも含まれる．白色のりん片狀晶．融點42.5～43 ℃．有機溶媒に可溶．リグノセリン酸とともにほ乳動物組織に広く分布している．
説明
Nervonic acid, also known as shark oil acid, is a monounsaturated omega-9 fatty acid that exists in nerve tissue and fish oil. It was first discovered in shark brain and is a component of cerebroside, the main source of in shark brain and shark oil. It is also found in the sphingolipids of white matter in human brain.
天然物の起源
Nervonic acid is abundant in King Salmon ( Chinook ) with 140 mg/100g, yellow mustard seed 83 mg/100g , flax seed 64 mg/ 100g, Sockeye salmon 40 mg/100g, sesame seed 35mg/100g, and macademia nuts 18 mg/100g.
定義
ChEBI: Nervonic Acid is a monounsaturated fatty acid with a 24-carbon backbone and the sole double bond originating from the 9th carbon from the methyl end, with this bond in the cis- configuration. It is a metabolite found in the aging mouse brain.
製造方法
Nervonic acid was shown to be identical with selachaleic acid isolated from whale oils. It is obvious that nervonic acid is probably the cis form of erucylacetic acid. Erucylacetic acid has been prepared from erucyl alcohol through the bromide and malonic ester synthesis and has been shown to be identical with nervonic acid obtained from hydrolysis of the cerebroside isolated from human brains.
Nervonic acid is also produced from oleic acid, that undergoes three consecutive chain elongation steps, catalyzed by elongases.Two carbon units are added in each step, with production of gadoleic acid, erucic acid, and finally, nervonic acid.
利點
Nervonic acid (NA, a monounsaturated long-chain fatty acid) has been found to alleviate neurodegeneration. In humans, abnormal NA levels are closely associated with a higher risk of developing neurological or psychiatric disorders such as psychosis, schizophrenia, or attention deficit disorder. Studies have shown that NA treatment can improve cognitive function, prevent demyelination and oligodendrocyte loss or apoptosis, improve cerebral blood flow, and upregulate brain-derived neurotrophic factor and myelin basic protein genes. In addition, NA can not only stimulate adipogenesis by regulating signaling pathways in human MSCs, but also improve the results of fat transplantation by reducing inflammation and stimulating angiogenesis.
生物學の機能
Nervonic acid is the only dual-action miracle substance that can repair nerve fibers that unblock damaged nerve pathways in the brain and promote nerve cell regeneration. It has been identified as important in the biosynthesis of nerve cell myelin. It is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids.
一般的な説明
Nervonic acids are the products of desaturation and elongation processes of various fatty acids such as palmitic acid, stearic acid, oleic acid, etc.
cis-15-テトラコセン酸 上流と下流の製品情報
原材料
準備製品