CRANAD 28
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- CAS番號.
- 1623747-97-6
- 化學名:
- 別名:
- 英語名:
- CRANAD 28
- 英語別名:
- CRANAD 28;CRANAD-28, 10 mM in DMSO;CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
- CBNumber:
- CB33152594
- 化學式:
- C27H23BF2N4O2
- 分子量:
- 484.3049264
- MOL File:
- 1623747-97-6.mol
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CRANAD 28 物理性質(zhì)
- 貯蔵溫度 :
- Store at -20°C
- 溶解性:
- DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- 外見 :
- A crystalline solid
- 色:
- Orange to red
- InChI:
- InChI=1S/C27H23BF2N4O2/c1-20-22(18-31-33(20)24-9-5-3-6-10-24)13-15-26-17-27(36-28(29,30)35-26)16-14-23-19-32-34(21(23)2)25-11-7-4-8-12-25/h3-19H,1-2H3
- InChIKey:
- DDFFGVTUEQJYQK-UHFFFAOYSA-N
- SMILES:
- CC1=C(C=NN1C1C=CC=CC=1)C=CC1=O[B+3]([F-])([F-])O=C(C=CC2C=NN(C3C=CC=CC=3)C=2C)[CH-]1
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
CRANAD 28 価格
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製品説明 |
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CRANAD 28 化學特性,用途語,生産方法
説明
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ)
in vitro and
in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (K
ds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
CRANAD 28 上流と下流の製品情報
原材料
準備製品
CRANAD 28 生産企業(yè)
Global( 49)Suppliers
- 1623747-97-6
- CRANAD 28
- 4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
- 1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron
- 4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)
- CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit
- CRANAD-28, 10 mM in DMSO