アジルサルタンメドキソミル 価格 もっと(2)

メーカー	製品番號(hào)	製品説明	CAS番號(hào)	包裝	価格	更新時(shí)間	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01MAS096463	アジルサルタンメドキソミル Azilsartan medoxomil	863031-21-4	1g	￥86500	2024-03-01	購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako)	W01MAS096463	アジルサルタンメドキソミル Azilsartan medoxomil	863031-21-4	5g	￥179400	2024-03-01	購(gòu)入

アジルサルタンメドキソミル 化學(xué)特性,用途語(yǔ),生産方法

効能

血圧降下薬, アンジオテンシンII受容體拮抗薬

説明

Azilsartan medoxomil (Edarbi), an angiotensin II receptor antagonist, was approved by the U.S. FDA in February 2011 for the treatment of hypertension in adults. The discovery of azilsartan was the result of a medicinal chemistry effort to identify an ARB with a different carboxylic acid isostere than the ones found in the marketed ARBs. Several of the marketed ARBs use a tetrazole group as a carboxylic acid isostere. The medicinal chemistry approach that led to azilsartan involved the replacement of this commonly used tetrazole with a 5-oxo-1,2,4-oxadiazole group. Azilsartan can be synthesized by Suzuki coupling of p-tolyl boronic acid to 2-bromobenzonitrile, followed by bromination of the methyl group. The bromide is displaced to introduce a protected 2-ethoxy-1H-benzo[d] imidazole-7-carboxylate. The cyano group is converted to a hydroxylamidine, followed by reaction with an alkyl-chloroformate and intramolecular cyclization to form the 5-oxo-1,2,4-oxadiazole ring. The acid is then deprotected and converted to a prodrug. The parent, azilsartan has been extensively characterized in vitro and compared with other marketed AT1 antagonists olmesartan, valsartan, telmisartan, irbesartan, and candesartan. Azilsartan was found to be a potent (IC₅₀=2.6 nM), selective, inverse agonist of the AT₁ receptor. From washout experiments, azilsartan was found have slow dissociation from the receptor and thus is characterized as an insurmountable antagonist.

定義

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension.

アジルサルタンメドキソミル 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

アジルサルタンメドキソミル 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10244	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58

863031-21-4(アジルサルタンメドキソミル)キーワード:

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• 863031-21-4
• 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester
• Azilsaran medoxomil
• (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzim
• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• Azilsartan medoxomil
• Azilsartan MedoxoMil(TAK 491)
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl 2-ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl)-1H-benziMidazole-7-carboxylate
• CS-306
• azilsartan medoxomil 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• Azilsartan Acid Medoxomil Ester
• Azilsartan Kamedoxomil Form I
• Azilsartan Medoxomil USP/EP/BP
• (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
• Azilsartan medoxomilQ: What is Azilsartan medoxomil Q: What is the CAS Number of Azilsartan medoxomil Q: What is the storage condition of Azilsartan medoxomil Q: What are the applications of Azilsartan medoxomil
• Azizartan ester
• Azilsartan MedoxiMil
• TAK 491
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
• Measartan potassium Impurity 36
• Azilsartan Medoxomil, 10 mM in DMSO
• アジルサルタンメドキソミル
• 3-[4′-({2-エトキシ-7-[(5-メチル-2-オキソ-1,3-ジオキソール-4-イル)メトキシカルボニル]-1H-ベンゾイミダゾール-1-イル}メチル)ビフェニル-2-イル]-1,2,4-オキサジアゾール-5-オール=カリウム塩
• イダービ
• アジルサルタンメドキソミル一カリウム塩
• アジルサルタン?メドキソミル
• カリウム3-[4′-[[2-エトキシ-7-[(5-メチル-2-オキソ-1,3-ジオキソール-4-イル)メトキシカルボニル]-1H-ベンゾイミダゾール-1-イル]メチル]-2-ビフェニリル]-1,2,4-オキサジアゾール-5-オラート
• (5-メチル-2-オキソ-2H-1,3-ジオキソール-4-イル)メチル 2-エトキシ-1-({2'-[5-(ポタッシオオキシ)-1,2,4-オキサジアゾール-3-イル]-[1,1'-ビフェニル]-4-イル}メチル)-1H-1,3-ベンゾジアゾール-7-カルボキシラート