イブチリド 化學(xué)特性,用途語,生産方法
効能
抗不整脈薬, カリウムチャネル遮斷薬
使用
Cardiac depressant
(anti-arrhythmic).
一般的な説明
Ibutilide, N-{4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl}methanesulfonamide (Corvert), aclass III antiarrhythmic belonging to the methanesulfonanilideclass of agents, is indicated for rapid conversion ofatrial fibrillation or atrial flutter to normal sinus rhythm.Unlike dofetilide, it is not highly specific for the delayedrectifier potassium currents (Ikr) and does have some affinityfor sodium channels.
臨床応用
Ibutilide (Corvert) is another methanesulfonanilide derivative , but unlike sotalol, it lacks
any β-adrenergic blocking activity. Like sotalol, it exhibits electrophysiologic effects characteristic of
Class III. Ibutilide is used only by intravenous infusion as its fumarate salt.
イブチリド 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品