3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)-
- CAS No.
- 185197-71-1
- Chemical Name:
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)-
- Synonyms
- (+)-Lercanidipine;Lercanidipine, (S)-;Lercanidipine Impurity 44;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)-
- CBNumber:
- CB98779459
- Molecular Formula:
- C36H41N3O6
- Molecular Weight:
- 611.74
- MDL Number:
- MOL File:
- 185197-71-1.mol
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)- Properties
Boiling point | 712.5±60.0 °C(Predicted) |
---|---|
Density | 1.177±0.06 g/cm3(Predicted) |
pka | 8.66±0.50(Predicted) |
FDA UNII | J8GF8BXI8S |
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)- Chemical Properties,Uses,Production
Uses
(S)-Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S)-Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S)-Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S)-Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S)-Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S)-Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S)-Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism[1].
References
[1] Lercanidipine's Antioxidative Effect Prevents Noise-Induced Hearing Loss DOI:10.3390/antiox13030327
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)- Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32351 | 58 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19927 | 58 |
QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24342 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 24803 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
TargetMol Chemicals Inc. | 58 |
QUALITY CONTROL SOLUTIONS LTD. | 58 |
TargetMol Chemicals Inc. | 58 |
View Lastest Price from 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, (4S)- manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-11-19 | Lercanidipine, (S)-
185197-71-1
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Lercanidipine, (S)-
185197-71-1
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.