Curculigoside C
- CAS No.
- 851713-74-1
- Chemical Name:
- Curculigoside C
- Synonyms
- Curculigoside C;β-D-Glucopyranoside, 4-hydroxy-2-[[(3-hydroxy-2,6-dimethoxybenzoyl)oxy]methyl]phenyl
- CBNumber:
- CB92743180
- Molecular Formula:
- C22H26O12
- Molecular Weight:
- 482.43
- MDL Number:
- MOL File:
- 851713-74-1.mol
Curculigoside C Chemical Properties,Uses,Production
Uses
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively[1].
in vivo
Curculigoside C (15, 30 and 60 mg/kg) exhibits rapid oral absorption (Tmax = 0.106 h, 0.111 h, and 0.111 h, respectively), high elimination (t1/2 = 2.022 h, 2.061 h, and 2.048 h, respectively) and low absolute bioavailability (2.01%, 2.13%, and 2.39%, respectively)[2].
Pharmacokinetic parameters of CC in rat plasma after intragastric administration[1].
| Dose (mg/kg) | t1/2 (h) | AUC0-60 (μg/L/h) | AUC0-∞ (μg/L/h) | F (%) | Vd (L/kg) | CLz (L/h/kg) | |
| 15 | 2.022 ± 0.184 | 0.106 ± 0.149 | 62.731 ± 10.149 | 66.310 ± 10.563 | 2.01 | 673.157 ± 116.509 | 231.036 ± 36.69 |
| 30 | 2.061 ± 0.325 | 0.111 ± 0.043 | 133.17 ± 48.434 | 140.656 ± 48.335 | 2.13 | 722.605 ± 316.306 | 234.188 ± 74.864 |
| 60 | 2.048 ± 0.227 | 0.111 ± 0.043 | 299.155 ± 80.954 | 316.980 ± 91.704 | 2.39 | 585.344 ± 124.289 | 201.905 ± 55.193 |
| 2.0 (i.v) | 1.153 ± 0.203 | - | 416.700 ± 70.401 | 420.700 ± 70.690 | - | 8.122 ± 1.973 | 4.869 ± 0.834 |
References
[1] Wu Q, et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7. DOI:10.1248/cpb.53.1065
[2] Di Wu, et al. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules. 2018 Dec 21;24(1):21. DOI:10.3390/molecules24010021
Curculigoside C Preparation Products And Raw materials
Raw materials
Preparation Products
Curculigoside C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38810 | 58 | |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5010 | 55 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20794 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4933 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5173 | 58 |
| Shanghai jingkang bioengineering co., ltd. | 021-54721350 13524668266 | 2881505714@qq.com | China | 7872 | 58 |