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ChemicalBook >> CAS DataBase List >>Exatecan

Exatecan

CAS No.
171335-80-1
Chemical Name:
Exatecan
Synonyms
exatecan alideximer;DX 8951;CS-147;Exatecan;1 Exatecan;Exatecan Base;Exatecan Impurity;Irinotecan Impurity 36;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione
CBNumber:
CB91009566
Molecular Formula:
C24H22FN3O4
Molecular Weight:
435.45
MDL Number:
MFCD00926120
MOL File:
171335-80-1.mol
MSDS File:
SDS
Last updated:2025-07-30 17:36:11

Exatecan Properties

Boiling point 818.4±65.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. Store at -20°C,protect from light
solubility Soluble in DMSO
pka 11.19±0.40(Predicted)
form Solid
color Off-white to gray
InChIKey ZVYVPGLRVWUPMP-FYSMJZIKSA-N
SMILES N1C2C3=C(CC[C@H](N)C3=C3CN4C(C=13)=CC1[C@](CC)(O)C(=O)OCC=1C4=O)C(C)=C(F)C=2
FDA UNII OC71PP0F89

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

Exatecan price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3519 Exatecan ≥98% (HPLC) 171335-80-1 5 mg $77.14 2025-07-31 Buy
Sigma-Aldrich SML3519 Exatecan ≥98% (HPLC) 171335-80-1 25 mg $328 2025-07-31 Buy
American Custom Chemicals Corporation API0005207 EXATECAN 95.00% 171335-80-1 5MG $1498.8 2021-12-16 Buy
ChemScene CS-2951 Exatecan 171335-80-1 500mg $2480 2021-12-16 Buy
ChemScene CS-2951 Exatecan 171335-80-1 100mg $2600 2021-12-16 Buy
Product number Packaging Price Buy
SML3519 5 mg $77.14 Buy
SML3519 25 mg $328 Buy
API0005207 5MG $1498.8 Buy
CS-2951 500mg $2480 Buy
CS-2951 100mg $2600 Buy

Exatecan Chemical Properties,Uses,Production

Description

Exatecan is a hexacyclic chemical compound analogous to camptothecin and used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination.

Definition

ChEBI: Exatecan is a pyranoindolizinoquinoline.

Biological Activity

Exatecan (DX-8951) is a DNA topoisomerase I (topoisomerase I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL) for cancer research.

in vitro

Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.

in vivo

Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.

Exatecan Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 140)Suppliers
Supplier Tel Email Country ProdList Advantage
Moxin Chemicals 		+8617320513646 Anna@molcoo.com China 9882 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12419 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9257 58

View Lastest Price from Exatecan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Exatecan pictures 2025-07-31 Exatecan
171335-80-1
 US $0.00-0.00 / mg 10mg 99%+ HPLC 1000 Moxin Chemicals
Exatecan pictures 2025-07-30 Exatecan
171335-80-1
 US $30.00-93.00 / mg 99.84% 10g TargetMol Chemicals Inc.
Exatecan pictures 2025-07-15 Exatecan
171335-80-1
 US $30.00-93.00 / mg 99.84% 10g TargetMol Chemicals Inc.
  • Exatecan pictures
  • Exatecan
    171335-80-1
  • US $0.00-0.00 / mg
  • 99%+ HPLC
  • Moxin Chemicals
  • Exatecan pictures
  • Exatecan
    171335-80-1
  • US $30.00-93.00 / mg
  • 99.84%
  • TargetMol Chemicals Inc.
  • Exatecan pictures
  • Exatecan
    171335-80-1
  • US $30.00-93.00 / mg
  • 99.84%
  • TargetMol Chemicals Inc.
10H,13H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT) (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione Exatecan CS-147 Exatecan Impurity 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)- Irinotecan Impurity 36 1 Exatecan DX 8951 exatecan alideximer Exatecan Base (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione 171335-80-1 1711335-80-1