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N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide

CAS No.
1995067-59-8
Chemical Name:
N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide
Synonyms
MCC7840;Emlenoflast;MCC7840 sodium;Inzomelid;N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide;N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-;MCC 7840,sulfonylurea,Emlenoflast,NLRP3,inhibit,NOD-like Receptor (NLR),MCC-7840,inflammatory,inflammasome,Inhibitor
CBNumber:
CB88058517
Molecular Formula:
C19H24N4O3S
Molecular Weight:
388.48
MDL Number:
MFCD34470841
MOL File:
1995067-59-8.mol
Last updated:2025-04-18 09:52:56

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 1.50±0.10(Predicted)
color White to off-white
FDA UNII SC4RYG0M76

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Chemical Properties,Uses,Production

Uses

Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases[1][2].

in vivo

Emlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice[2].
Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].

Animal Model:Male C57BL/6 mice (7-9 weeks)[2]
Dosage:4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:A single intravenousbolus or oral gavage
Result:I.v.: t1/2=3.39 h; AUC0-last=107097 ng?h/mL; CL=0.621 mL/min/kg.
P.o.: F=67.2%; Cmax=60467 ng/mL; t1/2=5.02 h.

IC 50

NLRP3 inflammasome: <100 nM (IC50)

References

[1] El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. DOI:10.3390/molecules25235533
[2] O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1521 58
Bide Pharmatech Ltd. 400-164-7117 13681763483 product02@bidepharm.com China 42446 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4649 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58

View Lastest Price from N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Emlenoflast pictures 2024-11-19 Emlenoflast
1995067-59-8
 US $116.00 / mg 98.19% 10g TargetMol Chemicals Inc.
  • Emlenoflast pictures
  • Emlenoflast
    1995067-59-8
  • US $116.00 / mg
  • 98.19%
  • TargetMol Chemicals Inc.
N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl) amino]carbonyl]-1-(1-methylethyl)-1H-Pyrazole-3-sulfonamide 1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)- N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide MCC7840 sodium Emlenoflast MCC7840 MCC 7840,sulfonylurea,Emlenoflast,NLRP3,inhibit,NOD-like Receptor (NLR),MCC-7840,inflammatory,inflammasome,Inhibitor Inzomelid 1995067-59-8